膳食视黄醇与食管鳞癌患者预后的关联研究

Association between dietary retinol and prognosis of patients with esophageal squamous cell carcinoma

【目的】探讨膳食视黄醇摄入量与食管鳞癌患者预后的关联。【方法】纳入2014年7月—2019年8月福建医科大学附属第一医院和福建省肿瘤医院经病理确诊的原发性食管鳞癌病例388例,分析视黄醇摄入量与患者基本特征之间的关系,使用Kruskal⁃Wallis秩和检验分析视黄醇摄入量与营养素之间的关联,运用Cox比例风险回归模型分析膳食视黄醇与食管鳞癌预后关联。【结果】不同视黄醇摄入分组的食管鳞癌患者在性别、年龄、TNM分期、肿瘤长度、营养素摄入特征等的分布均衡可比(P>0.05)。多因素Cox回归分析显示,高视黄醇摄入组的患者预后较好(总生存期:HR=0.279,95%CI:0.150~0.520,P<0.001;无病生存期:HR=0.306,95%CI:0.181~0.516,P<0.001)。【结论】视黄醇摄入量与食管鳞癌患者的预后存在关联,高摄入视黄醇可能改善食管鳞癌患者的预后。

[Objective]To explore the association between dietary retinol intake and prognosis of patients with esophageal squamous cell carcinoma.[Methods]The study enrolled 388 cases with primary esophageal squamous cell carcinoma that was pathologically diagnosed in the first affiliated hospital of Fujian medical university and the cancer hospital of Fujian medical university from July 2014 to August 2019.Chisquare test was used to determine the relationship between retinol and patients'characteristics.Kruskal-Wallis rank sum test was used to analyze the relationship between retinol and multiple nutrients.Cox proportional hazards regression model was used to explore the association between dietary retinol and esophageal squamous cell carcinoma.[Results]Patients with esophageal squamous cell carcinoma did not significantly differ in gender,age,TNM stage,tumor length or nutrient intake by different retinol intakes(P>0.05).Multivariate Cox regression analysis showed that the high retinol intake group had a better prognosis(overal survial:HR=0.279,95%CI:0.150‒0.520,P<0.001;disease-free survival:HR=0.306,95%CI:0.181‒0.516,P<0.001).[Conclusion]High dietary retinol intake may improve the prognosis of patients with esophageal squamous cell carcinoma.