基于网络拓扑和多种生物信息融合的关键蛋白质识别算法

Essential protein identification algorithm based on the combination of network topology and multiple biological information

关键蛋白质的识别有助于了解细胞存活的基本需求,并为疾病治疗找到新方法,但是蛋白质自身携带着复杂的生物特性,仅依赖网络拓扑特性不能精准地判断其关键性.因此,提出一种新方法来提高识别关键蛋白质的准确率.首先,考虑网络拓扑特性以及蛋白质在不同亚细胞中的重要程度,定义了SNC方法;其次,利用蛋白质在亚细胞与复合物信息中的特性定义了SIDC方法;最后,通过融合网络拓扑结构和多源生物信息,提出了关键蛋白质识别算法CTB.在YDIP、YMIPS和Krogan数据集上利用精准率-查全率等多种评估方法进行实验,结果表明CTB算法提高了识别关键蛋白质的性能.

Identification of essential proteins helps to understand the basic needs of cell survival and find new methods for disease treatment. Protein itself carries complex biological characteristics, and it is impossible to accurately judge their criticality only by network topology. In this paper, a new method is proposed to improve the accuracy of identifying essential proteins. Firstly, considering the network topology and the importance of proteins in different sub-cells, an indicator called SNC is proposed. Secondly, SIDC indicatoris defined by using the characteristics of proteins in subcellular and complex information. Finally, based on the network topology and multi-source biological information, a new protein recognition algorithm CTB is proposed. Experiments on YDIP, YMIPS, Krogan data sets using accuracy recall and other evaluation methods show that the method in this paper improves the performance of identifying key proteins.