我国中老年人慢性炎症性疾病分析

Analysis of chronic inflammatory diseases in middle-aged and elderly people in China

目的探讨中老年人高血压、空腹血糖受损、高脂血症和超敏C反应蛋白(hs-CRP)异常的患病情况及其相关指标与hs-CRP水平的相关性。方法采用2015年中国健康与养老追踪调查数据,以10281名中老年人(年龄≥45岁)为研究对象,采用横断面分析方法,对不同年龄段中老年人的高血压、空腹糖耐量受损、高脂血症和hs-CRP异常的发生率进行比较,分析hs-CRP水平与血压、血糖和血脂水平的相关性。结果随着年龄增加,收缩压(SBP)、空腹血糖(FPG)、低密度脂蛋白(LDL-C)、hs-CRP显著升高(P<0.05),体重指数(BMI)、腰围、舒张压(DBP)、甘油三酯(TG)显著降低(P<0.001)。低龄老年组和高龄老年组的高血压、空腹血糖受损和hs-CRP异常的发生率显著高于中年组(P<0.001),而高脂血症的发生率显著低于中年组(P=0.007)。在中年组和低龄老年组,hs-CRP与SBP、DBP、FPG、TG、总胆固醇(TC)呈显著正相关(P<0.001);在高龄老年组,hs-CRP仅与FPG、TG呈显著正相关(P=0.001);hs-CRP与高密度脂蛋白(HDL-C)在三个年龄组均呈显著负相关(P<0.001)。结论高血压、空腹血糖受损和hs-CRP异常的发生率随着年龄的增加而升高,高脂血症的发生率随着年龄的增加而降低,hs-CRP与中老年人的血压、血糖和血脂指标存在显著的相关关系。

Objective To investigate the prevalence of hypertension,impaired fasting glucose,hyperlipidemia and abnormal high-sensitivity C-reactive protein(hs-CRP)and the relationship between hs-CRP and blood pressure,fasting plasma glucose(FPG)and lipid levels in middle-aged and elderly people.Methods Data from China Health and Retirement Longitudinal Study(CHARLS)in 2015,10,281 middle-aged and elderly people≥45 years old were selected as subjects.The incidence of hypertension,impaired fasting glucose,hyperlipidemia and abnormal hs-CRP in different age groups were compared,and the associations between hs-CRP level and blood pressure,blood glucose and lipid indexes were analyzed.Results With the increase of age,systolic blood pressure(SBP),fasting blood glucose(FPG),low-density lipoprotein cholesterol(LDL-C)and hs-CRP were significantly increased(P<0.05),while body mass index(BMI),waist circumference,diastolic blood pressure(DBP)and triglyceride(TG)were significantly decreased(P<0.001).The incidence of hypertension,impaired fasting glucose and abnormal hs-CRP in elderly aged≥65 years old was significantly higher than that in the middle age group(P<0.001),while the incidence of hyperlipidemia was significantly lower(P=0.007).Hs-CRP was positively correlated with SBP,DBP,FPG,TG and total cholesterol(TC)in the group aged 45~79 years old(P<0.001).In the elderly group aged≥80 years old,hs-CRP was only positively correlated with FPG and TG(P=0.001).Besides,hs-CRP was negatively correlated with high-density lipoprotein cholesterol(HDL-C)in all three age groups(P<0.001).Conclusion The incidence of hypertension,impaired fasting glucose and abnormal hs-CRP increased with the elevated age,and the incidence of hyperlipidemia decreased.Hs-CRP was significantly correlated with blood pressure,blood glucose and lipid indexes in middle-aged and elderly people.