脑小血管病与急性缺血性卒中静脉溶栓后出血转化的关系研究进展

Research progress on the relationship between cerebral small vessel disease and hemorrhage transformation after intravenous thrombolysis in acute ischemic stroke

随着人口老龄化加剧和神经影像学的快速发展,脑小血管病受到越来越多的重视,静脉溶栓治疗是急性缺血性卒中时间窗内有效的治疗方法。大量研究表明,发生急性缺血性卒中前存在的脑小血管病可能会增加静脉溶栓后出血转化的风险,但结果仍有很多争议。本文主要从脑小血管病的不同亚型、磁共振成像总负担与急性缺血性卒中患者静脉溶栓后出血转化的影响研究进行阐述,旨在为临床提供参考依据。

With the aging of the population and the rapid development of neuroimaging,more and more attention has been paid to cerebrovascular diseases.Intravenous thrombolytic therapy is an effective treatment method in the time window of acute ischemic stroke.A large number of studies have shown that the existence of cerebrovascular diseases before the occurrence of acute ischemic stroke may increase the risk of hemorrhage transformation after intravenous thrombolysis,but the results are still controversial.This article mainly reviews the research on the influence of different subtypes of cerebrovascular disease,the total burden of magnetic resonance imaging and the transformation of bleeding after intravenous thrombolysis in patients with acute ischemic stroke,in order to provide reference for clinical practice.