血清NT-pro-BNP及Lp-PLA2水平与急性冠状动脉综合征合并2型糖尿病患者冠状动脉病变程度的相关性分析

Correlation analysis of serum NT-pro-BNP and Lp-PLA2 levels with the severity of coronary artery lesions in patients with acute coronary syndrome and type 2 diabetes mellitus

目的探讨血清N末端前脑钠肽(NT-pro-BNP)及脂蛋白磷脂酶A2(Lp-PLA2)水平与急性冠状动脉综合征(acute coronary syndrome,ACS)合并2型糖尿病(type 2 diabetes mellitus,T2DM)患者冠状动脉病变程度的相关性。方法选择2018年6月至2020年10月期间山西省长治医学院附属和平医院收治的68例ACS合并T2DM患者作为观察组,对照组为52例单纯ACS患者。检测两组患者的血清NT-pro-BNP及Lp-PLA2水平,分析探血清NT-pro-BNP及Lp-PLA2水平与ACS合并T2DM患者冠状动脉病变程度的相关性,筛选ACS合并T2DM患者中重度冠状动脉病变的影响因素。结果观察组的血清NT-pro-BNP[(349.18±45.98 vs 235.68±26.37)ng/L]及Lp-PLA2[(421.84±55.84 vs 318.62±36.69)ng/ml]水平皆高于对照组(P<0.05)。中重度组的血清NT-pro-BNP[(374.35±39.42 vs 320.88±35.41)ng/L]及Lp-PLA2[(452.67±48.32 vs 387.16±40.45)ng/ml]水平皆高于轻度组(P<0.05)。血清NT-pro-BNP及Lp-PLA2水平与ACS合并T2DM患者冠状动脉病变程度皆呈正相关(r=-0.585,P=0.000;r=-0.595,P=0.000)。血清NT-pro-BNP及Lp-PLA2是ACS合并T2DM患者中重度冠状动脉病变的危险因素(P<0.05)。结论ACS合并T2DM患者血清NT-pro-BNP及Lp-PLA2水平与冠状动脉病变程度有关。

Objective To investigate the correlation between serum N-terminal pro-brain natriuretic peptide(NT-pro-BNP)and lipoprotein phospholipase A2(Lp-PLA2)levels and the severity of coronary artery lesions in patients with acute coronary syndrome(ACS)complicated with type 2 diabetes mellitus(T2DM).Methods A total of 68 patients with ACS and T2DM who were admitted to our hospital from Jun.2018 to Oct.2020 were selected as the experimental group,and the control group was 52 patients with simple ACS.The serum NT-pro-BNP and Lp-PLA2 levels of the two groups of patients were detected,and the correlation between the serum NT-pro-BNP and Lp-PLA2 levels and the degree of coronary artery disease in patients with ACS complicated with T2DM was analyzed to screen for ACS complicated with T2DM.Influencing factors of moderate to severe coronary artery disease in diabetic patients were selected.Results The serum levels of NT-pro-BNP[(349.18±45.98 vs 235.68±26.37)]ng/L and Lp-PLA2[(421.84±55.84 vs 318.62±36.69)]ng/mL in the experimental group were higher than those in the control group(P<0.05).The levels of serum NT-pro-BNP[(374.35±39.42 vs 320.88±35.41)]ng/L and Lp-PLA2[(452.67±48.32 vs 387.16±40.45)]ng/mL in the moderate-severe group were higher than those in the mild group(P<0.05).Serum NT-pro-BNP and Lp-PLA2 levels were positively correlated with the severity of coronary artery lesions in patients with ACS and T2DM(r=-0.585,P=0.000;r=-0.595,P=0.000).Serum NT-pro-BNP and Lp-PLA2 were risk factors for moderate to severe coronary artery disease in patients with ACS complicated with T2DM(P<0.05).Conclusion Serum levels of NT-pro-BNP and Lp-PLA2 in patients with ACS complicated with type 2 diabetes mellitus are related to the degree of coronary artery disease.