VEGF、TGF-β1与复发性急性髓系白血病患者危险层级的关系研究

Study on relationship between VEGF,TGF-β1 and risk level in patients with recurrent acute myeloid leukemia

目的:观察血管内皮生长因子(VEGF)、转化生长因子-β1(TGF-β1)在复发性急性髓系白血病(AML)患者不同危险层级中的表达,并分析VEGF、TGF-β1与不同危险层级的关系。方法:纳入2019年10月至2021年10月收治的92例复发性AML患者进行研究,根据相关指南对92例患者进行预后危险层级评估;在评估前对患者进行相关检查和资料收集,检查项目包括血小板计数(PLT)、白细胞计数(WBC)、中性粒细胞计数(NE)、血红蛋白(Hb)和VEGF、TGF-β1等,观察各指标在不同危险层级患者中的表达,采用Kendall’s tau-b相关系数,分析VEGF、TGF-β1与复发性AML不同危险层级的关系。结果:92例复发性AML患者,经评估后分为低危患者32例,中危患者40例,高危患者20例,不同危险层级患者一般资料比较,差异无统计学意义。不同危险层级患者PLT、WBC、NE、Hb、VEGF、TGF-β1比较,差异有统计学意义(P<0.05);但PLT、WBC、NE、Hb在低危和中危,中危和高危患者之间比较,差异无统计学意义;在低危和高危之间相比较,差异有统计学意义(P<0.05)。采用Kendall’s tau-b相关系数检验,VEGF与复发性AML患者危险层级呈正相关(r>0,P<0.05);TGF-β1与复发性AML患者危险层级呈负相关(r<0,P<0.05)。结论:血清VEGF、TGF-β1表达在复发性AML患者不同危险层级中差异有统计学意义,其中VEGF与复发性AML患者危险层级呈正相关,TGF-β1与复发性AML患者危险层级呈负相关。

Objective:To observe the expression of vascular endothelial growth factor(VEGF)and transforming growth factorβ1(TGF-β1)in different risk levels of patients with recurrent acute myeloid leukemia(AML),and analyze the relationship between VEGF,TGF-β1 and different risk levels.Methods:A total of 92 patients with recurrent AML admitted to the hospital from October 2019 to October 2021 were included in the study,and the prognosis risk level of 92 patients was evaluated according to relevant guidelines;relevant examinations and general data collection were conducted for the patients before the assessment.The examination items included platelet(PLT),white blood cell count(WBC),neutrophil count(NE),hemoglobin(Hb),VEGF,TGF-β1,etc.Observed the expression of each index in patients with different risk levels,and analyzed the relationship between VEGF,TGF-β1 and different risk levels of recurrent AML by Kendall’s tau-b correlation coefficient.Results:After evaluation,92 patients with recurrent AML were identified as 32 low-risk patients,40 moderate risk patients and 20 high-risk patients.There was no statistical significant difference in comparison of the general data of patients at different risk levels.Compared PLT,WBC,NE,GHB,VEGF and TGF-β1 among patients at different risk levels,the difference was statistically significant(P<0.05).However,there was no statistical significant difference in comparison of PLT,WBC,NE and Hb between low-risk and moderate risk patients,and between moderate and high-risk patients;compared between low risk and high risk,the difference was statistically significant(P<0.05).By Kendall’s tau-b correlation coefficient test,VEGF was positively correlated with the risk level of patients with recurrent AML(r>0,P<0.05);TGF-β1 was negatively correlated with the risk level of recurrent AML(r<0,P<0.05).Conclusion:The expressions of serum VEGF and TGF-β1 were significantly different in different risk levels of the patients with recurrent AML.VEGF was positively correlated with the risk level of the patients with recurrent AML,and TGF-β1 was negatively correlated with the risk level of the patients with recurrent AML.