中医药辅助放疗与化疗减毒增效研究进展

Research progress on the toxicity-reducing and efficacy-enhancing action of traditional Chinese medicine in radiotherapy and chemotherapy

放疗与化疗是临床治疗肿瘤的主要手段,在有效抑制肿瘤生长的同时,所引起的不良反应不容忽视,包括心脏毒性、肾毒性、骨髓抑制和黏膜炎等,严重影响肿瘤患者的生活质量。中医药辅助放疗与化疗在肿瘤治疗过程中有着独特的优势,不但可以减少放疗与化疗产生的不良反应,还可以增强放疗与化疗的治疗效果。文章综述了近年来中医药辅助放疗与化疗减毒增效的研究进展,从中医药缓解放疗与化疗诱导的炎症反应、氧化应激、骨髓和免疫系统损伤几个方面进行阐述,为后续中医药辅助放疗与化疗减毒增效的研究提供参考。

Radiotherapy and chemotherapy are the mainstay tumors clinical therapeutic modalities.While effectively inhibiting tumor growth,the toxic and side effects should not be ignored,including cardiotoxicity,nephrotoxicity,myelosuppression and mucositis,etc.,which severely affect the quality of life of tumor patients.Traditional Chinese medicine(TCM)has the advantage in reducing adverse effects of radiotherapy and chemotherapy in tumor treatment,which can not only alleviate the toxic and side effects,but also enhance the therapeutic effect.This paper reviews the research progress of TCM-assisted Radiotherapy and chemotherapy in reducing toxicity and efficiency in recent years,and elaborates them from inflammatory reaction,oxidative stress,bone marrow and immune system damages.With TCM-assisted radiotherapy and chemotherapy,which provides reference resources for further TCM-assisted radiotherapy and chemotherapy in reducing toxicity and increasing efficiency.