雷公藤多苷治疗儿童紫癜性肾炎的作用机制研究进展

Research progress on the mechanism of Tripterygium glycosides in the treatment of purpura nephritis in children

紫癜性肾炎是继发于过敏性紫癜的肾小球疾病,一般预后良好,仍有部分患者发展至终末期肾病,影响儿童的身心发展。雷公藤多苷是卫矛科雷公藤的根部提取物,在儿童肾脏病的使用已有40余年的历史,但因其对生殖功能的影响,限制了其在临床上的使用。临床上发现雷公藤多苷能减少紫癜性肾炎患儿的血尿及蛋白尿,且不良反应可控,临床上及基础实验已对雷公藤治疗儿童紫癜性肾炎的作用机制开展了系列的研究,文章对相关研究进行总结归纳,为临床上使用雷公藤多苷治疗儿童紫癜性肾炎提供参考。

Purpura nephritis is a glomerular disease secondary to Henoch-Schonlein purpura(HSP),which generally has a good prognosis,but some patients could still reach the end-stage renal disease,affecting the physical and mental development of children.Tripterygium glycosides is the root extract of Tripterygium wilfordi,which has been used in pediatric kidney disease for more than 40 years.However,because of its impact on reproductive function,it limits its clinical use.Clinically found that Tripterygium glycosides can reduce hematuria and proteinuria in children with purpura nephritis,and adverse reactions are controllable,clinical and basic experiments have carried out a series of studies on the mechanism of action of Tripterygium wilfordii in the treatment of children's purpura nephritis.This paper summarized relevant studies,providing a reference for the clinical use of Tripterygium glycosides in the treatment of children's purpura nephritis.