摘要
生物钟系统是机体为了适应地球的昼夜更替而进化出的一套内在适应性计时机制,生物钟紊乱与肠道菌群失调以及代谢异常关系密切。中医痰湿体质是多种代谢性疾病的共同土壤。除饮食不节以外,起居失常也是影响痰湿体质代谢紊乱的重要因素,但其具体机制尚不明确。文章以生物钟紊乱、肠道菌群、代谢异常三者之间的调控作用为切入点,阐释起居失常影响痰湿体质的作用机制,探讨生物钟通过影响肠道菌群对痰湿体质的形成,以及对代谢性疾病易感性可能发挥的作用。提出起居失常导致的生物钟紊乱可能会通过肠道菌群对痰湿体质产生影响,为揭示痰湿体质的分子机制以及临床调体提供新的科学视角。
The circadian clock system is a set of internal adaptive timing mechanisms evolved by the body to adapt to the earth's day and night alternation.Circadian dysrhythmia is closely related to intestinal flora dysbiosis and metabolic disorder.The phlegm-dampness constitution of traditional Chinese medicine is the common soil of a variety of metabolic diseases.In addition to improper diet habits,irregular daily living is also an important factor affecting the metabolic disorder of the phlegm-dampness constitution,but its specific mechanism is not clear.The present work,based on the interactions between circadian dysrhythmia,intestinal flora,and metabolic abnormalities,aims to elucidate the mechanism of irregular daily living contributing to the occurrence of metabolic disorder of the phlegm-dampness constitution;and explore the possible role of circadian dysrhythmia on the formation of the phlegm-dampness constitution and the possibile role of susceptibility to metabolic disease through regulating the composition and structure of intestinal flora.It is proposed that the circadian dysrhythmia caused by irregular daily living may affect the phlegm-dampness constitution through intestinal flora,which provides a new scientific perspective for revealing the molecular mechanism of the phlegm-dampness constitution as well as its clinical intervention.
作者
王潇璐
万瑾毅
姚海强
WANG Xiao-lu;WAN Jin-yi;YAO Hai-qiang(Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2022年第12期7333-7336,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金项目(No.81973714,No.81803970)
中华中医药学会“青年人才托举工程”(No.CACM-2019-QNRC2-A01)
北京中医药大学高层次人才项目(No.2021-XJ-KYQD-004)
中央高校基本科研业务费专项资金资助(No.2020-JYB-XJSJJ-003)
关键词
痰湿体质
起居失常
生物钟紊乱
肠道菌群
代谢异常
Phlegm-dampness constitution
Irregular daily living
Circadian dysrhythmia
Intestinal flora
Metabolic disorder