期刊文献+

非编码RNA在心血管疾病中的研究进展 被引量:1

Research progress of non-coding RNA in cardiovascular disease
原文传递
导出
摘要 心血管疾病是导致全球人类死亡的主要原因。研究发现非编码RNA在心血管疾病中发挥了重要作用, 不仅具有成为心血管疾病诊断特异性生物标志物的潜力, 而且有望成为治疗的靶点。因此现对非编码RNA在心血管疾病发病中的诊断价值及调控作用的研究进展进行综述, 为心血管疾病的诊断及治疗提供新的思路。 Cardiovascular disease is the leading cause of human deaths in the world.Studies have found that non-coding RNA plays an important role in cardiovascular disease.Non-coding RNA is not only a potential specific biomarker for cardiovascular disease diagnosis,but also a therapeutic target for the disease.In this paper,the research progress of the diagnostic value and regulatory role of non-coding RNA in the pathogenesis of cardiovascular disease was reviewed in order to provide new ideas for the diagnosis and treatment of cardiovascular diseases.
作者 宋文良 刘春峰 Song Wenliang;Liu Chunfeng(Pediatric Intensive Care Unit,Shengjing Hospital of China Medical University,Shenyang 110000,China)
出处 《中华实用儿科临床杂志》 CAS CSCD 北大核心 2022年第19期1504-1508,共5页 Chinese Journal of Applied Clinical Pediatrics
基金 国家自然科学基金(81971810) 辽宁省科技重大专项计划(2020JH1/10300001)。
关键词 非编码RNA 心血管疾病 生物标志物 Non-coding RNA Cardiovascular disease Biomarker
  • 相关文献

参考文献2

二级参考文献44

  • 1Cheng Y, Ji R, Yue J, et al. MicroRNAs are aberrantly ex- pressed in hypertrophic heart: do they play a role in cardiac hypertrophy? Am J Patho12007 ; 170:1831-1840.
  • 2Sun Q, Zhang Y, Yang G, et al. Transforming growth factor- β-regulated miR-24 promotes skeletal muscle differentiation. Nucleic Acids Res 2008; 36:2690-2699.
  • 3Xiao H, Zhang YY. Understanding the role of transforming growth factor-13 signaling in the heart: overviews of studies us- ing genetic mouse models. Clin Exp Pharmacol Physio12008; 35:335-341.
  • 4Divakaran V, Adrogue J, Ishiyama M, et al. Adaptive and mal- adaptive effects of SMAD3 signaling in the adult heart after hemodynamic pressure overloading. Circ Heart Fail 2009; 2:633-642.
  • 5Umans L, Cox L, Tjwa M, et al. Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis. Am JPathol 2007; 170:1460-1472.
  • 6van Rooij E, Sutherland LB, Thatcher JE, et al. Dysregula- tion of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci USA 2008; 105:13027-13032.
  • 7Rogler CE, LeVoci L, Ader T, et al. MicroRNA-23b cluster microRNAs regulate transforming growth factor-beta/bone morphogenetic protein signaling and liver stem cell differen- tiation by targeting Smads. Hepatology 2009: 50:575-584.
  • 8Chinchilla A, Lozano E, Daimi H, et al. MicroRNA profiling during mouse ventricular maturation: a role for miR-27b mod- ulating Mef2c expression. Cardiovasc Res 2011 ; 89:98-108.
  • 9Ren XP, Wu J, Wang x, et al. MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by target- ing heat-shock protein 20. Circulation 2009; 119:2357-2368.
  • 10Lin Z, Murtaza 1, Wang K, Jiao J, Gao J, Li PF. miR-23a func- tions downstream of NFATc3 to regulate cardiac hypertrophy. Proc Natl Acad Sci USA 2009; 106:12103-12108.

共引文献59

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部