CMR-FT量化的左心房应变对心肌梗死患者MACE的预测价值

The prognostic value of left atrial strain assessed by cardiac MR feature tracking to major adverse cardiovascular events in myocardial infarction patients

目的:利用心脏磁共振特征跟踪(CMR-FT)技术测定包括左心房(LA)应变在内的LA功能参数,初步探讨LA功能对心肌梗死(MI)患者发生主要心血管不良事件(MACE)的预测价值。方法:收集2015年7月—2021年11月在昆明医科大学第二附属医院经临床及CMR确诊的MI患者112例,根据随访结果分为无MACE组和MACE组。所有患者均行CMR检查发现有明确心肌梗死灶,利用CMR-FT技术获得包括LA应变在内的LA功能参数。比较两组患者的临床基线资料及CMR参数,分析各参数对MI患者出现MACE的预测价值。结果:共纳入MI患者112例,其中MACE组50例,无MACE组62例。两组患者LA 3期应变及应变率、LA存储期及导管期射血分数、左心室射血分数(LVEF)、左心室收缩末期容积标化值、梗死容积、年龄有显著统计学差异(P<0.05)。LA存储期射血分数、LA存储期应变及应变率、LA导管期应变、LVEF与MI患者发生MACE呈负相关(rs<-0.3,P<0.05)。LA导管期及泵血期应变率、梗死容积、左心室收缩末容积标化值及年龄与MI患者发生MACE呈正相关(rs>0.3,P<0.05)。ROC分析提示导管期应变及应变率、存储期应变及应变率、存储期射血分数、梗死容积、LVEF及年龄对预测MI患者预后均有一定价值(AUC>0.7,P<0.05),其中导管期应变及应变率的预测效能最大(AUC=0.74,P<0.001)。结论:CMR-FT技术可以量化LA应变参数并全面评估LA功能,对MI患者MACE的发生具有预测价值。LA应变参数预测效能总体优于LA容积参数及左心室功能参数,其中导管期应变及应变率对MI患者发生MACE预测效能最大。

Objective:The aims of this study were to evaluate The Prognostic Value of left atrial(LA)strain assessed with Cardiac MR feature tracking(CMR-FT)to major adverse cardiovascular events(MACE)in Myocardial Infarction(MI)Patients.Methods:Between July 2015 and November 2021,112 MI patients at admission were included in this study.According to the follow-up results,the study populationts were divided into MACE group and non-MACE group.All study participants underwent CMR and LA strain parameters were quantifified by CMR-FT.Various clinical and CMR parameters including LA strain were assessed for association with MACE in MI patients.Results:A total of 112 participants were included.During follow-up,50 patients reached the composite endpoint.There were significant differences between the LA strain,LA strain rate,LA reservoir ejection fraction,LA conduit ejection fraction,left ventricular ejection fraction(LVEF),left ventricular end-systolic volume index,percentage of infarct volume and age(P<0.05).Spearman correlation analysis showed that LA reservoir ejection fraction,LA reservoir strain and strain rate,LA conduit strain and LVEF were slightly negatively correlated with MACE in MI paitents(r<-0.3,P<0.05).LA conduit strain rate,LA contraction rate,percentage of infarct volume,left ventricular end-systolic volume index and age were slightly positivly correlated with MACE in MI paitents(r<-0.3,P<0.05).ROC analysis revealed that LA reservoir strain and strain rate,LA conduit strain and strain rate,LA reservoir ejection fraction,LVEF and percentage of infarct volume had certain value for prognosis(AUC>0.7,P<0.05).LA conduit strain and strain rate were the best predictors of MACE among these parameters.Conclusion:CMR-FT can quantify the LA strain and comprehensively evaluate the LA function,which has predictive value for MACE in MI patients.The results showed that the predictive efficacy of LA strain parameters was superior to LA volume parameters and left ventricular function parameters in general,and the strain rate at catheter stage had the greatest predictive efficacy for MACE in MI patients.LA strain demonstrated better predictive power than LA volume index and left ventricular function parameters.LA conduit strain and strain rate were the best predictors of MACE.