青年脑卒中后抑郁危险因素的Meta分析

Risk factors for post-stroke depression in young adults: a Meta-analysis

目的:采用Meta分析评价青年脑卒中后抑郁的危险因素,为预防青年脑卒中后抑郁提供循证学依据。方法:通过计算机检索中国知网(CNKI)、维普数据库(VIP)、万方数据库、PubMed、the Cochrane Library、EMbase、Web of Science数据库中关于青年脑卒中后抑郁危险因素的病例对照研究及队列研究。检索时间为建库至2022年5月10日。由2人独立进行文献筛选、资料提取和质量评价。使用Stata 15.1软件进行分析。结果:最终纳入9项病例对照研究和队列研究进行定量分析。Meta分析显示,青年脑卒中后抑郁的危险因素包括:性别[OR=1.58,95%CI(1.19,2.08),P<0.000 01]、婚姻[OR=2.07,95%CI(1.19,3.63),P<0.000 01]、职业[OR=3.33,95%CI(1.23,8.98),P<0.000 01]、家庭功能[OR=0.48,95%CI(0.31,0.74),P<0.000 01]、糖尿病[OR=2.27,95%CI(1.62,3.18),P<0.000 1]、神经功能缺损评分[OR=0.14,95%CI(0.06,0.35),P<0.000 1]。结论:现有证据表明,针对性别、婚姻、职业等危险因素进行干预有助于降低青年脑卒中后抑郁的发病率。

Objective:To evaluate the risk factors of poststroke depression in young adults by Meta-analysis, and to provide evidence-based evidence for the prevention of poststroke depression in young adults.Methods:Case-control or cohort studies on risk factors for poststroke depression in young adults were retrieved from CNKI,VIP,WanFang Datebase, PubMed, the Cochrane Library, EMbase, and Web of Science.The retrieval time was from the establishment of each database to May 10, 2022.Literature screening, data extraction and quality evaluation were conducted independently by two people.The Stata 15.1 software was used for analysis.Results:A total of 9 case-control studies and cohort studies were included for quantitative analysis.Meta-analysis showed that risk factors for poststroke depression in young adults included: gender[OR=1.58,95%CI(1.19,2.08),P<0.000 01],marriage[OR=2.07,95%CI(1.19,3.63),P<0.000 01],occupation[OR=3.33,95%CI(1.23,8.98),P<0.000 01],family function[OR=0.48,95%CI(0.31,0.74),P<0.000 01],diabetes[OR=2.27,95%CI(1.62,3.18),P<0.000 1],neurological deficit score[OR=0.14,95%CI(0.06,0.35),P<0.000 1].Conclusion:Existing evidence shows that the intervention of gender, marriage, occupation and other risk factors is helpful to reduce the incidence of poststroke depression in young people.