前列腺癌寡转移治疗的探讨

Management of oligometastatic prostate cancer

前列腺癌寡转移是一种介于局限期肿瘤和肿瘤广泛转移的中间状态。尽管不同文献对寡转移的定义,提出了不同的看法,但普遍认为盆腔外的转移灶不超过5个。针对寡转移前列腺癌的治疗,近年来越来越多的数据更支持积极治疗。目前文献报道针对原发灶和转移灶的治疗尝试,毒性和副作用可以耐受。寡转移前列腺癌治疗的复杂性也对未来临床研究的设计和实践提出了挑战。

Oligometastatic prostate cancer(Oligo-mPCa)is an intermediate stage of cancer spread between localized disease and widespread metastases.Although the definition of oligometastatic prostate cancer varies in literatures,a clinical diagnosis made based on up to five extra-pelvic lesions is commonly for use.More and more data supporting the active treatment on oligo-mPCa.Studies suggest that interventions such as radical prostatectomy and local or metastasis-directed radiotherapy is safe and tolerable in oligo-mPCa.However,clinical trials focusing on oligo-mPCa are still challenging due to the complicated settings of oligo-mPCa.