添加共生元的乳蛋白部分水解配方奶粉对有牛奶过敏史幼儿肠道症状及菌群的影响

Effects of Partially Hydrolyzed Formula with Synbiotics on the Gastrointestinal Symptoms and Gut Microbiota of Toddlers with Cow’s Milk Allergy History

目的:探讨对有牛奶蛋白过敏史幼儿采用添加共生元的乳蛋白部分水解配方奶粉喂养的可行性。方法:收集我院2019年12月至2021年1月治疗的有轻度胃肠道症状、有轻度牛奶蛋白过敏史且已痊愈的幼儿,以添加共生元的乳蛋白部分水解配方奶粉喂养干预3个月。随访记录干预前后幼儿的肠道症状、肠道菌群(采集粪便,16srDNA测序)等情况。结果:本研究共纳入1~2岁幼儿38例,以添加共生元的乳蛋白部分水解配方奶粉喂养干预3个月后,幼儿的身高和体质量增加,功能性便秘症状改善,肠道耐受性良好;肠道菌群多样性增加,个体差异减小;双歧杆菌百分比上升,假单胞菌目、莫拉菌科等有害菌群百分比下降。结论:喂养添加共生元的乳蛋白部分水解配方奶粉有利于有牛奶蛋白过敏史幼儿的肠道菌群结构改善及便秘症状缓解。

Objective:To explore the effects of partially hydrolyzed formula with synbiotics on the gastrointestinal symptoms and gut microbiota of toddlers with cow’s milk allergy history.Methods:We included toddlers with cow’s milk allergy who were treated in our hospital from December 2019 to January 2021,and recovered but have mild gastrointestinal symptoms.The participants were fed with partially hydrolyzed formula with synbiotics and followed up for three months.The toddlers’gastrointestinal symptoms and feces were collected before and after the intervention,and the gut microbiota was tested by 16 srDNA sequencing.Results:Thirty-eight toddlers aged 1-2 years old were included in the study,whose height and weight were significantly increased and symptom of functional constipation were significantly reduced after 3-month intervention.Other intestinal symptoms were not significantly changed and the formula was well tolerated.The proportion of Bifidobacterium was obviously increased,and the increase of Bifidobacterium was correlated with the improvement of constipation symptoms.Meanwhile,Pseudomonas and Moraxellaceae were significantly decreased after the intervention.Conclusion:Partially hydrolyzed formula with synbiotics could improve the gut microbiota composition and relieve functional constipation symptoms in toddlers with cow’s milk allergy history.