干眼的再生疗法研究进展

Research progress of regenerative therapy for dry eye

干眼是眼睛表面组织以及泪液出现病变的一种多诱因疾病,当前临床治疗干眼多为对症治疗,包括眼部湿润、消炎,但其存在部分局限性。干眼主要是以泪膜稳态失衡为特征的眼部疾病,其病因包括泪膜不稳定、泪液高渗性、眼表炎症和损伤以及神经感觉异常等。干眼症患者发生率大约为5%~50%,且女性与老年人的发生率较高。相关研究认为,泪液高渗性和泪膜不稳定性,其属于一种核心发病因素。同时,高渗性以及炎症对人体眼部产生的影响比较大。随着医学研究逐渐深入,细胞凋亡在干眼中的作用逐渐受到重视。同时,临床生物学研究的关键主要是病变组织再次生长,尤其是间充质干细胞,其具有免疫调节性、多重性以及营养性。基于此,本文通过收集干眼相关文献内容,对干眼进行概述,并综述再生疗法相关研究进展,进而为干眼临床治疗提供参考方案。

Dry eye is a multiple inducement disease of eye surface tissue and tear lesions.Currently,the clinical treatment of dry eye is mostly symptomatic treatment,including moist eye and anti-inflammatory,but it has some limitations.Dry eye is an eye disease mainly characterized by the imbulance of tear film stability.Its causes include tear film instability,tear hyperosmolality,ocular surface inflammation and injuries and nerve sensory abnormalities.The incidence of dry eye is about 5%-50%,and the incidence of women and the elderly is high.According to relevant studies,tear hyperosmolality and tear film instability belong to a core pathogenic factor.At the same time,hypertonic and inflammation have a greater impact on human eyes.With the gradual deepening of medical research,the role of apoptosis in dry eye has been gradually emphasized.At the same time,the key of clinical biology research is the re growth of diseased tissues,especially mesenchymal stem cells,which have immune regulation,multiplicity and nutrition.Based on this,this article summarizes dry eye by collecting relevant literature,and reviews the research progress of regenerative therapy,so as to provide a reference plan for clinical treatment of dry eye.