更年期泌尿生殖系统综合征阴道雌激素递送系统

Vaginal estrogen delivery system in Genitourinary syndrome of menopause

更年期泌尿生殖系统综合征(GSM)是发病率较高的围绝经期症状,并会随着时间的推移进行性加重,但由于患者和医生的认知及重视程度不足,目前并未得到及时的适当诊治。目前对这一局部症状的疗法包括绝经激素治疗(MHT)和非激素方法,其中阴道局部递送雌激素的MHT因其安全性和有效性可靠,是目前治疗GSM的一线方案。对近几年GSM的局部雌激素递送系统(DDS)主要有片剂、胶囊、栓剂、乳膏、阴道环(IVRs)和凝胶,本文就相关的上市药物及近年的研发进展进行综述,为临床工作提供一定的参考。

Genitourinary syndrome of menopause(GSM)is a highly prevalent perimenopausal symptom that progressively worsens over time but it is currently not appropriately treated in a timely manner due to lack of awareness and attention by patients and their physicians.Current therapies for this localized symptom include Menopause Hormone Therapy(MHT)and non-hormonal approaches,with MHT for local vaginal delivery of estrogen being the current first-line treatment option for GSM due to its reliable safety and efficacy.The main topical estrogen Drug Delivery System(DDS)for GSM in recent years include tablets,capsules,suppositories,creams,vaginal rings(IVRs)and gels.This article reviews the relevant marketed drugs and the progress of their development in recent years to provide some reference in clinical.