清肺解毒方治疗小儿细菌性肺炎急性期热毒壅肺证的疗效观察

Clinical Efficacy of Self-prepared Qingfei Jiedu Decoction on Children Bacterial Pneumonia in Acute Stage(Syndrome of Heat Toxin Obstructing Lung)

目的观察清肺解毒方治疗小儿细菌性肺炎(热毒壅肺证)急性期的临床疗效。方法选取2020年1月—2021年1月期间西安交通大学附属儿童医院收治的63例小儿细菌性肺炎患者作为研究对象,根据随机数字表法将其分为治疗组32例和对照组31例。治疗组予以西医常规治疗联合清肺解毒方,对照组仅予以西医常规治疗。治疗14 d后,观察比较两组患儿中医症状评分、临床观察指标[体温恢复时间、咳嗽消失时间、啰音消失时间及住院时间]、炎性因子水平[C反应蛋白(C-Reactive Protein,CRP)、白介素-6(Interleukin-6,IL-6)、白细胞计数(White Blood Cell Count,WBC)、降钙素原(Procalcitonin,PCT)]及临床疗效。结果治疗后对照组总有效率80.65%(25/31)与治疗组总有效率87.50%(28/32)比较,差异有统计学意义(P<0.05)。治疗后两组患儿中医症状评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组中医症状评分较对照组明显降低,差异有统计学意义(P<0.05)。治疗后治疗组患儿体温恢复时间、咳嗽消失时间、啰音消失时间及住院时间均明显优于对照组,差异有统计学意义(P<0.05)。两组患儿治疗后CRP、IL-6、WBC、PCT炎性因子指标水平均较治疗前下降,差异有统计学意义(P<0.05);且治疗组明显低于对照组,差异有统计学意义(P<0.05)。结论清肺解毒方能有效缓解热毒壅肺证小儿细菌性肺炎的临床症状,缩短患儿住院时间,提高临床疗效,其机制可能与通过降低炎性因子水平,改善机体感染情况有关。

Objective To investigate the clinical efficacy of self-prepared Qingfei Jiedu Decoction on children bacterial pneumonia in acute stage(syndrome of heat toxin obstructing lung).Methods A total of 63 children with bacterial pneumonia admitted to the Xi′an Children′s Hospital of Xi′an Jiaotong University from January 2020 to January 2021 were selected as the subjects,and they were divided into a treatment group(32 cases)and a control group(31 cases)by random number table.The treatment group was given conventional western medicine treatment combined with self-prepared Qingfei Jiedu Decoction,while the control group was given conventional western medicine treatment only.After 14 days of treatment,the traditional Chinese medicine(TCM)symptom score,clinical observation indexes(body temperature recovery time,cough disappearance time,rale disappearance time,length of hospital stay),level of inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),white blood cell(WBC)count,procalcitonin(PCT)]and clinical efficacy of the two groups were observed and compared.Results The total effective rate of the treatment group(87.5%,28/32)was higher than that of the control group(80.65%,25/31)(P<0.05).After treatment,the TCM symptom scores and the levels of CRP,IL-6,WBC,PCT of the two groups were lower than those before treatment(both P<0.05),and the treatment group had more decrease than the control group(P<0.05).The body temperature recovery time,cough disappearance time,rale disappearance time and length of hospital stay in the treatment group were shorter than those in the control group(P<0.05).Conclusion Self-prepared Qingfei Jiedu Decoction could effectively relieve the clinical symptoms of bacterial pneumonia in children with syndrome of heat toxin obstructing lung,shorten the hospitalization time and enhancethe clinical efficacy.The mechanism might be related to reducing the level of inflammatory factors and improving the infection of the body.