硫糖铝混悬凝胶联合奥美拉唑肠溶胶囊治疗隆起糜烂性胃炎效果及对胃肠激素的影响

Effect of sucralfate suspension gel combined with omeprazole enteric coated capsule in the treatment of protuberant erosive gastritis and its influence on serum gastrointestinal hormone levels

目的观察硫糖铝混悬凝胶联合奥美拉唑肠溶胶囊治疗隆起糜烂性胃炎(REG)的效果及对患者血清胃肠激素水平的影响。方法选取2019年7月—2021年8月中国人民解放军联勤保障部队第910医院收治的REG患者81例,按照随机数字表法分为联合组(n=41)和对照组(n=40)。2组患者均予常规治疗,在此基础上,对照组患者给予奥美拉唑肠溶胶囊治疗,联合组在对照组的基础上联合硫糖铝混悬凝胶治疗,2组患者均持续治疗8周。比较2组患者临床疗效、治疗前后炎性因子、胃肠激素水平及不良反应。结果联合组患者的总有效率为92.68%,高于对照组的75.00%(χ^(2)=4.698,P=0.030)。治疗8周后,2组患者白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及C反应蛋白(CRP)水平均低于治疗前,且联合组低于对照组(P均<0.01);2组患者胃蛋白酶原Ⅰ(PGⅠ)及胃泌素-17(GAS-17)水平均上升,胃蛋白酶原Ⅱ(PGⅡ)水平均下降,且联合组变化幅度均大于对照组(P<0.05或P<0.01)。对照组与联合组患者的不良反应总发生率比较差异无统计学意义(7.50%vs.14.63%,χ^(2)=1.043,P=0.307)。结论硫糖铝混悬凝胶联合奥美拉唑肠溶胶囊治疗REG可通过降低炎性因子水平,调节胃肠激素水平,进而提高临床疗效,且不增加不良反应发生率。

Objective To observe the effect of sucralfate suspension gel combined with omeprazole enteric coated capsule in the treatment of protuberant erosive gastritis(REG)and its influence on the level of serum gastrointestinal hormones.Methods 81 patients with REG were selected from the 910 th Hospital of PLA Joint Logistic Support Force from July 2019 to August 2021,according to the method of random number table,they were divided into combined group(n=41)and control group(n=40).The patients in both groups were treated with routine therapy,on this basis,the patients in control group were treated with omeprazole enteric coated capsules,while the patients in combined group were treated with sucralfate suspension gel on the basis of control group,the patients in both groups were treated for 8 weeks.The clinical efficacy,levels of inflammatory factors,gastrointestinal hormones before and after treatment and adverse reactions of the two groups were compared.Results The total effective rate of combined group was 92.68%,higher than 75.00%of control group(χ^(2)=4.698,P=0.030).After 8 weeks of treatment,the interleukin-6(IL-6)and tumor necrosis factor TNF-α(TNF-α)and C-reactive protein(CRP)levels were lower than those before treatment,and combined group were lower than control group(P<0.01);The levels of pepsinogen[HT6]Ⅰ[HT5"](PG[HT6]Ⅰ[HT5"])and gastrin-17(GAS-17)increased in both groups,while the levels of pepsinogen[HT6]Ⅱ[HT5"](PG[HT6]Ⅱ[HT5"])decreased in both groups,and the changes in combined group were greater than those in control group(P<0.05 or P<0.01).There was no significant difference in the total incidence of adverse reactions between control group and combined group(7.50%vs.14.63%,χ^(2)=1.043,P=0.307).Conclusion The combination of sucralfate suspension gel and omeprazole enteric coated capsule in the treatment of REG can improve the clinical efficacy without increasing the incidence of adverse reactions by reducing the level of inflammatory factors and regulating the level of gastrointestinal hormones.