基于数据挖掘探讨中医药治疗勃起功能障碍的临床运用现况及规律

The current status and rules of clinical application of traditional Chinese medicine for treating erectile dysfunction via data mining

目的 通过数据挖掘及分析探讨中医药治疗勃起功能障碍(ED)的临床运用现况及规律。方法 系统搜集中国知网(CNKI)、万方数据知识服务平台(Wanfang Data)、维普(CQVIP)等数据库2001年-2021年中医药治疗ED的临床研究文献,运用Excel、SPSS 22.0、Weka 3.8、Cytoscape3.7.1等软件对文献中涉及中药的类别、性味及归经等进行规范化数据库管理,并通过统计学处理挖掘分析相关数据。结果 共筛选纳入相关方剂319首,涉及不同中药260味,其中频次≥32次的有35味,用药以补虚药为主,性味多甘、辛、温,归经多为肝、肾、脾;常见药对包括仙茅-淫羊藿、枳壳-柴胡、郁金-柴胡等;置信度较高的药组为:当归-牛膝-柴胡、白芍-茯苓-柴胡、柴胡-白术-当归等;通过聚类分析和因子分析,共得出6组聚类结果和12对公因子,其中公因子1贡献率为6.421%。结论 中医药治疗ED主要通过温肾壮阳、疏肝解郁、益气活血等,侧面反映ED的发生以肾虚、肝郁、气虚为本,血瘀为标,肾虚血瘀、肝郁气滞、气虚血瘀等为ED发病的主要病机特点。

Objective To explore the current status and rules of clinical use of traditional Chinese medicine(TCM) in the treatment of erectile dysfunction(ED) through data mining and analysis. Methods Clinical research literatures on TCM treatment of ED from CNKI, Wanfang Data, CQVIP and other databases from 2001 to 2021 were systematically collected. Excel, SPSS 22.0, Weka 3.8, Cytoscape3.7.1 and other softwares were used to conduct standardized database management of literatures on the categories, nature and flavor, and warp normalization of TCM, and relevant data were mining and analyzed through statistical processing. Results A total of 319 related prescriptions were screened and included, involving 260 different herbal medicines, of which 35 had a frequency of ≥ 32. The drugs used are mainly deficiency tonics, with sweet, pungent and warm flavors, and with the liver, kidney and spleen as the main meridians;common herb pairs include Xianmao-Yinyanghuo, Zhike-Chaihu, Yujin-Chaihu, etc. The herb groups with a higher confidence were Danggui-Niuxi-Chaihu, Baishao-Fuling-Chaihu, and Chaihu-Baizhu-Danggui, etc. Through cluster analysis and factor analysis, 6 sets of clustering results and 12 pairs of common factors were obtained, of which the contribution of common factor 1 was 6.421%. Conclusions TCM treats ED mainly through warming the kidney and strengthening the Yang, soothing liver-Qi stagnation, benefiting Qi and invigorating blood, etc. It laterally reflects that the occurrence of ED is based on kidney deficiency, liver stagnation and Qi deficiency and marked by blood stasis. Kidney deficiency and blood stasis, liver-Qi stagnation, Qi deficiency and blood stasis are major features of ED pathogenesis.