摘要
目的 分析配偶宫颈HPV感染的男性HPV感染情况。方法 对配偶宫颈HPV感染的男性受试者341例进行HPV检测,分析HPV感染与包皮过长的关系、不同年龄段HPV感染情况以及HPV分型。其中43例HPV感染且包皮过长的男性患者进行包皮环切术+抗病毒治疗,17例进行抗病毒治疗。随访分析3、6、12和18个月转阴情况。结果 341例受试者中,HPV感染246例(72.14%)。包皮过长者260例(76.25%),包皮过长组HPV感染率为75.38%,高于包皮正常组的61.73%(P<0.05)。各年龄段HPV感染率比较无统计学差异(P>0.05)。HPV单型感染占52.44%(129/246),多型感染占47.56%(117/246)。其中,高危型最常见的依次是HPV 52(22.36%)、HPV 16(19.51%)、HPV 51(15.04%)和HPV 58(15.04%),低危型最常见的是HPV 42(12.20%)。包皮环切术+抗病毒治疗组与抗病毒治疗组HPV总转阴率比较无统计学差异(41.86%vs. 35.29%)(P>0.05)。结论 配偶宫颈HPV感染的男性HPV感染率较高。包皮过长与HPV感染有关,但包皮环切术和抗病毒治疗不会影响HPV转阴。
ObjectiveTo analyze the of HPV infection in males whose spouses infected with cervical HPV.Methods The HPV infection was detected in 341 males whose spouses infected with cervical HPV.The relationship of HPV infection and redundant prepuce,HPV infection in different age groups and HPV genotyping were analyzed.Among them,43 male patients with HPV infection and redundant prepuce received circumcision plus antiviral therapy,and 17 cases received antiviral therapy.The patients were followed up and the negative conversion was analyzed at the time points of 3,6,12 and 18 months after treatment.Results Of 341 cases,246 cases(72.14%)were infected with HPV and 260 cases(76.25%)were with redundant prepuce.The HPV infection rate in males with redundant prepuce was 75.38%,which was higher than those with normal prepuce of 61.73%(P<o.05).There was no significant difference in HPV infection rate among different age groups(P>0.05).The males accounted for 52.44%(129/246)of monotype HPV infection and 47.56%(117/246)of polytypic HPV infection.The most common high-risk type was HPV 52(22.36%),HPV 16(19.51%),HPV 51(15.04%)and HPV 58(15.04%),and the most common low-risk type was HPV 42(12.20%).There was no significant difference in the total negative conversion rate between the circumcision plus antiviral therapy group and antiviral therapy group(41.86%vs.35.29%)(P>0.05).Conclusion The HPV infection rate of the males whose spouses infected with cervical HPV is higher,in whom redundant prepuce is associated with HPV infection,but circumcision and antiviral treatment have no effect on HPV negative conversion rate.
作者
张峰磊
潘连军
潘锋
ZHANG Fenglei;PAN Lianjun;PAN Feng(Department of Andrology,Affiliated Nanjing Maternity and Child Health Care Hospital,Nanjing Medical University,Nanjing 210004,CHINA)
出处
《江苏医药》
CAS
2022年第12期1260-1263,共4页
Jiangsu Medical Journal
基金
国家自然科学基金(81771572)
“十三五”南京市卫生青年人才培养工程项目(QRX17071)
江苏省妇幼保健协会科研课题(FYX202207)。