生物标志物在急性肾损伤进展至慢性肾脏病中的研究进展

Research Progress of Biomarkers in Progression from Acute Kidney Injury to Chronic Kidney Disease

在发生急性肾损伤(AKI)后,有一部分患者即使血清肌酐、尿量、肾小球滤过率恢复正常,但肾脏结构仍遗留不同程度的损伤进而导致不完全或适应不良性修复,最终进展至慢性肾脏病(CKD)。早期识别这一高危人群有助于及时采取干预措施、改善患者的远期预后。近些年的研究发现生物标志物的测定有助于早期识别AKI进展至CKD的高危患者,因此本文就AKI进展至CKD的相关生物标志物展开综述。

After acute kidney injury(AKI), even though serum creatinine, urine volume and glomerular filtration rate return to normal, some patients still have different degrees of renal structure damage, which leads to incomplete or maladaptive repair, and finally progresses to chronic kidney disease(CKD). Early identification of this high-risk group is helpful to take timely intervention measures and improve the long-term prognosis of patients. Recent studies have found that the determination of biomarkers is helpful for early identification of patients at high risk of progression from AKI to CKD. Therefore, this article reviews the biomarkers related to progression from AKI to CKD.