心肌型脂肪酸结合蛋白与新型冠状病毒肺炎轻重症的相关性

Correlation between heart type fatty acid binding protein and mild&severe COVID-19

目的分析轻型/重型新型冠状病毒肺炎(COVID-19)患者的临床特征,探讨心肌型脂肪酸结合蛋白(H-FABP)与COVID-19轻重症的相关性。方法回顾性分析2022年6月前重庆大学附属三峡医院收治的超敏肌钙蛋白T(hs-cTnT)表达阴性的COVID-19患者40例,根据《新型冠状病毒肺炎诊疗方案(试行第八版)》诊断标准,将患者分为轻型和重型两组,比较两组外周血中H-FABP表达水平差异。结果符合纳入标准的COVID-19患者共40例,其中轻型组20例,重型组20例,与轻型组相比,重型组年龄更大[(41.9±10.5)vs(58.2±16.3)岁],且合并糖尿病比例更高(P均<0.05)。通过比较两组血清H-FABP表达水平发现,重型组H-FABP水平明显高于轻型组[(3.97±1.80)vs(6.88±3.90)μg/L,P<0.05]。结论在hs-cTnT表达阴性的COVID-19患者中,血清H-FABP表达水平与COVID-19疾病严重程度相关,H-FABP可能作为一个更加敏感且独立的心肌损伤因子用于COVID-19疾病分型。

Objective To analyze the clinical characteristics of patients with mild&severe corona virus disease 2019(COVID-19)and explore the correlation between herart fatty acid binding protein(H-FABP)and mild&severe COVID-19.Methods Totally 40 patients with negative expression of high-sensitivity troponin T(hs-cTnT)admitted to the Chongqing University Three Gorges Hospital before June 2022 were retrospectively analyzed.According to the diagnostic criteria of“Diagnosis and Treatment Protocol for COVID-19(Trial Version 8)”,the patients were enrolled into the mild and severe groups.The expression levels of H-FABP in peripheral blood were compared between the two groups.Results Eligible 40 COVID-19 patients representing 20 cases in the mild group and 20 cases in the severe group were included.Compared with the mild group,the patients in the severe group were older([41.9±10.5]vs[58.2±16.3])years,and the proportion of patients with diabetes was higher(all P<0.05).H-FABP level in the severe group was significantly higher than that in the mild group([3.97±1.80]vs[6.88±3.90]μg/L;[P<0.05],respectively).Conclusion In COVID-19 patients with negative hs-cTnT expression,serum H-FABP expression level is associated with the severity of COVID-19 disease.H-FABP may serve as a more sensitive and independent myocardial injury factor to contribute to the disease typing of COVID-19.