两药单日生长激素激发试验在矮小症儿童的临床价值

Clinical value of the two combination of single-day growth hormone provocation test in short stature children

目的探讨溴吡斯的明(pyridostigmine,PD)与可乐定(clonidine)单日联合激发试验在矮小症儿童的临床价值。方法选取2019年6月-2021年6月在潍坊市人民医院小儿内科就诊的125例矮小症患儿,随机分成两组,试验组采用溴吡斯的明与可乐定联合激发试验,对照组采用精氨酸与可乐定单日联合激发试验,化学发光法检测生长激素(GH),比较两种方法GH缺乏的阳性率及不良反应的发生率,以评估该GH激发试验的有效性和安全性。结果两组GH激发试验的GH峰值水平分别为(17.44±5.56)μg/L和(17.88±5.60)μg/L,差别无统计学意义(P>0.05)。两组GH峰值阳性率与不良反应发生率差异均无统计学意义(均P>0.05)。结论溴吡斯的明与可乐定联合激发试验和精氨酸与可乐定联合激发试验得出的结果具有很高的一致性,可以用于评估矮小症儿童的GH水平,是一种简单、有效的试验方法。

Objective To explore the clinical value of single-day combined Pyridostigmine Bromide and clonidine test on short stature(SS)children.Methods The children(n=125)presenting with SS visiting the Department of Pediatric Internal Medicine,Weifang People's Hospital from June 2019 to June 2021 were selected,and they were randomized into two groups.Pyridostigmine Bromide and clonidine provocation test was implemented for children in the experimental group,the single-day combined arginine and clonidine test was implemented for children in the control group.Growth hormone(GH)was tested by the chemiluminescence method.The positive rate and incidence of adverse reactions of GH deficiency between two methods were compared to evaluate the efficacy and safety of GH provocation test.Results The average GH peak level for provocation test in two groups was(17.44±5.56)μg/L and(17.88±5.60)μg/L,respectively,no difference was statistically significant(P>0.05).Differences in GH peak positive rate and adverse reaction rate between two groups weren't statistically significant(all P>0.05).Conclusion The outcome of combined Pyridostigmine Bromide and clonidine provocation test is highly consistent with that of the combined arginine and Alonidine provocation test,it is eligible to be used to evaluate GH level in SS children,and it is identified as a simple and effective test method.