淋巴结包膜外侵犯的研究进展及其对肺癌预后的意义

Advances in research on extracapsular lymph node invasion and its prognostic significance in lung cancer

淋巴结的转移状态是包括肺癌在内的多种恶性肿瘤的重要预后因素。近期,多项研究发现,即便处于同一N分期的患者,其预后也可大不相同,提出对相同N分期的亚群患者应进行更为细致的划分,其中就包括纳入淋巴结包膜外转移(ENE)的因素。本文对ENE的定义、分类/分级、影像学诊断、病理学诊断、相关分子标志物及其与肺癌患者预后之间的关系进行了回顾。

The status of lymph node metastasis is an important prognostic factor for many malignant tumors,including lung cancer.In the 8th edition of the TNM staging system for lung cancer,the T staging had obvious changes and refinements,but the N staging had little changes.Recently,several studies have found that the prognosis of patients with the same N stage can vary greatly,suggesting that a more detailed subgroup of patients with the same N stage should be subdivided,including the inclusion of extra-capsular lymph node metastases(ENE).In this review,we reviewed the definition,classification/grading,imaging diagnosis,pathological diagnosis,related molecular markers and their relationship with the prognosis of lung cancer patients.