摘要
淋巴结的转移状态是包括肺癌在内的多种恶性肿瘤的重要预后因素。近期,多项研究发现,即便处于同一N分期的患者,其预后也可大不相同,提出对相同N分期的亚群患者应进行更为细致的划分,其中就包括纳入淋巴结包膜外转移(ENE)的因素。本文对ENE的定义、分类/分级、影像学诊断、病理学诊断、相关分子标志物及其与肺癌患者预后之间的关系进行了回顾。
The status of lymph node metastasis is an important prognostic factor for many malignant tumors,including lung cancer.In the 8th edition of the TNM staging system for lung cancer,the T staging had obvious changes and refinements,but the N staging had little changes.Recently,several studies have found that the prognosis of patients with the same N stage can vary greatly,suggesting that a more detailed subgroup of patients with the same N stage should be subdivided,including the inclusion of extra-capsular lymph node metastases(ENE).In this review,we reviewed the definition,classification/grading,imaging diagnosis,pathological diagnosis,related molecular markers and their relationship with the prognosis of lung cancer patients.
作者
王怀宇
宗东江
周传宏
刘颖汇
朱京娜
刘杰
吴科
韩勇
Wang Huaiyu;Zong Dongjiang;Zhou Chuanhong;Liu Yinghui;Zhu Jingna;Liu Jie;Wu Ke;Han Yong(Thoracic Surgery Department,PLA Airforce Medical Center,Beijing 100142,China)
出处
《中华胸心血管外科杂志》
CSCD
北大核心
2022年第12期764-768,共5页
Chinese Journal of Thoracic and Cardiovascular Surgery