肥大细胞在仔猪过敏性腹泻中的作用

Role of mast cells in allergic diarrhea in piglets

断奶仔猪采食食源性过敏原易引发过敏性腹泻。过敏原与在肠道肥大细胞上的免疫球蛋白E(IgE)结合,使肥大细胞活化,活化后的肠道肥大细胞通过释放组胺、类胰蛋白酶、糜蛋白酶和多种细胞因子等介质介导肠道紧密连接屏障,改变肠道通透性,引起腹泻等过敏反应。文章综述肥大细胞在仔猪过敏性腹泻中的应用,以期为相关后续研究及临床应用提供参考。

Feeding food allergens to weanling piglets is easy to cause allergic diarrhea.Allergens bind to immunoglobulin E(IgE)on intestinal mast cells to activate them.The activated intestinal mast cells mediate the intestinal tight junction barrier through the release of histamine,tryptase,chymotrypsin and a variety of cytokines,changing the intestinal permeability and causing allergic reactions such as diarrhea.The article reviews the application of mast cells in allergic diarrhea of piglets,to provide reference for related follow-up research and clinical application.