肌肉减少症和骨关节炎相关性研究进展

Research progress on the correlation between sarcopenia and osteoarthritis

目的对肌肉减少症和骨关节炎(osteoarthritis,OA)的相关性研究进展进行综述。方法广泛查阅近年国内外关于肌肉减少症和OA的基础研究和临床研究,从流行病学现状、危险因素、发病机制、临床治疗、对关节置换的影响5个方面分析和总结两者的相关性。结果肌肉减少症和OA是老年人群的常见疾病,具有较高患病率且能增加彼此患病风险。两者共有多种危险因素,并且在发病机制和临床治疗上显示出消极的相互作用和影响,从而参与彼此的疾病进程和降低治疗效益。临床研究显示肌肉减少症能从多方面影响全关节置换术后康复效果和增加术后并发症发生风险。结论目前研究结果表明肌肉减少症和OA在上述5个方面具有相关性且相互影响,但需要更多研究进一步阐明两者关系,为认识、预防和诊疗两种疾病提供更多理论依据。

Objective To review the research progress on the correlation between sarcopenia and osteoarthritis(OA).Methods The basic and clinical studies at home and abroad in recent years on sarcopenia and OA were extensively reviewed.The correlation between sarcopenia and OA was analyzed and summarized from five aspects:epidemiological status,risk factors,pathogenesis,clinical treatments,and the impact on joint arthroplasty.Results Sarcopenia and OA are common diseases in the elderly with high prevalence and can increase the ill risk of each other.They share a set of risk factors,and show negative interactive and influence on pathogenesis and clinical treatments,thus participating in each other’s disease process and reducing the treatment benefits.Clinical studies show that sarcopenia can affect the rehabilitation effect and increase the risk of postoperative complications after total joint arthroplasty in many ways.Conclusion Current research results show that sarcopenia and OA are related and can be mutually affected in the above5 aspects,but more studies are needed to further clarify the relationship between them,so as to provide more theoretical basis for the understanding,prevention,diagnosis,and treatments of the two diseases.