3D打印多孔钛合金在肿瘤切除术后应用的研究进展

Application and research progress of three-dimentional printed porous titanium alloy after tumor resection

目的对3D打印多孔钛合金在肿瘤切除术后应用的研究进展进行综述,为其后续临床应用及基础研究提供参考。方法查阅近年来3D打印多孔钛合金在肿瘤切除术后应用的相关文献,对单纯3D打印多孔钛合金植入体的性能及在肿瘤切除术后的临床应用、抗肿瘤3D打印多孔钛合金植入体的研究进展3个方面进行综述。结果3D打印技术能够调节多孔钛合金孔隙参数,使其拥有与骨相当的生物力学性能,适宜的孔隙参数利于诱导骨生长、促进患者术后骨骼系统及相关功能恢复、提高患者术后生活质量。单纯3D打印多孔钛合金植入体可通过术前个性化设计更准确地匹配肿瘤切除术后骨缺损,使其与外科切缘紧密贴合,提高手术精度与效率,术后早中期随访结果表明术后植入体松动、下沉、骨折等并发症明显减少,骨骼稳定性增强。抗肿瘤3D打印多孔钛合金植入体获得抗肿瘤性能的途径主要包括对单纯3D打印多孔钛合金植入体进行涂层及载药处理,目前尚处于基础研究阶段,并已取得一定进展。结论单纯3D打印多孔钛合金植入体适用于肿瘤切除术后大尺寸且形态复杂的骨缺损患者,可通过涂层及载药途径实现植入体抗肿瘤化功能。

Objective To review the current research and application progress of three-dimentional(3D)printed porous titanium alloy after tumor resection,and provide direction and reference for the follow-up clinical application and basic research of 3D printed porous titanium alloy.Methods The related literature on research and application of 3D printed porous titanium alloy after tumor resection in recent years was reviewed from three aspects:performance of simple 3D printed porous titanium alloy,application analysis of simple 3D printed porous titanium alloy after tumor resection,and research progress of anti-tumor 3D printed porous titanium alloy.Results 3D printing technology can adjust the pore parameters of porous titanium alloy,so that it has the same biomechanical properties as bone.Appropriate pore parameters are conducive to inducing bone growth,promoting the recovery of skeletal system and related functions,and improving the quality of life of patients after operation.Simple 3D printed porous titanium alloy can more accurately match the bone defect after tumor resection through preoperative personalized design,so that it can closely fit the surgical margin after tumor resection,and improve the accuracy and efficiency of the operation.The early and mid-term follow-up results show that its application reduces the postoperative complications such as implant loosening,subsidence,fracture and so on,and enhances the bone stability.The anti-tumor performance of 3D printed porous titanium alloy mainly includes coating and drug-loading treatment of pure 3D printed porous titanium alloy,and some progress has been made in the basic research stage.Conclusion Simple 3D printed porous titanium alloy is suitable for patients with large and complex bone defects after tumor resection,and the anti-tumor effect of 3D printed porous titanium alloy can be achieved through coating and drug delivery.