肌少症与心血管疾病相关性的研究现状

Research status of the relationship between sarcopenia and cardiovascular disease

随着老龄化进程的加快、国人生活方式的改变,心血管疾病位居导致伤残和死亡的前列。老年群体更是已经成为心血管疾病患病的主力军。国内外专家发现,另一常见的老年病肌少症的发病率逐年提升,心血管疾病患者中肌少症的发病率较单纯肌少症患者高达快3倍。越来越多的研究表明,肌少症与心血管疾病在炎症、胰岛素抵抗、氧化应激、自噬等发病路径,及抗炎、抗氧化、改善胰岛素抵抗等防治策略方面存在明显的正向联系。本文概述了肌少症与心血管疾病共同的发病路径、相关性及防治策略方面的研究现状。

With the acceleration of the aging process and the change of Chinese lifestyle,cardiovascular diseases are among the leading causes of disability and death.The elderly population has become the main component of the sufferers of cardiovascular disease.According to the studies from the experts home and abroad,it was found that the incidence of sarcopenia,another common geriatric disease,was increasing year by year.The incidence of sarcopenia in the patients with cardiovascular disease was nearly three times higher than that in the patients with simple sarcopenia.More and more studies have shown that sarcopenia is positively related to cardiovascular diseases in the pathogenesis of inflammation,insulin resistance,oxidative stress,autophagy and other pathways,as well as in the prevention and treatment strategies of anti inflammation,anti-oxidation and improving insulin resistance.This paper summarizes the common pathogenesis,correlation and prevention and treatment of sarcopenia and cardiovascular disease.