全血细胞及分类计数对急性冠脉综合征发生及预后的作用研究进展

Research progress on the effect of whole blood cell count and classification on the occurrence and prognosis of acute coronary syndrome

急性冠脉综合征(ACS)是指冠状动脉内不稳定的粥样硬化斑块破裂或糜烂继发新鲜血栓形成所导致的心脏急性缺血综合征,近几年我国ACS患者人数呈逐年递增趋势。全血细胞主要包括红细胞、白细胞、血小板计数三大类,当其表达水平或者细胞形态发生变化及异常时,可能会对包括ACS在内的一些心血管疾病的产生、发展进程及预后具有预测及指示作用,因此全血细胞计数(CBC)常作为一种血液检查方式,用于评估人体的健康状况是否发生异常。本研究在对ACS相关研究报道进行文献调研时发现,在ACS的发生及预后过程中,全血细胞及其分类计数这一指标均表现出较强的相关性,并且该指标检测操作简便,费用低廉,临床应用优势明显。此外,在更深层次的干预措施效应评价中,CBC可作为有效的临床指标;最新研究证实了全血细胞是影响ACS发生及预后的重要因素。本文拟结合ACS研究报道,挖掘全血细胞及其分类计数对ACS发生及预后的预测作用,就全血细胞及其分类计数在ACS风险预测方面的研究进行综述。

Acute coronary syndromes(ACS)are acute ischemic syndromes of the heart caused by the rupture of unstable atherosclerotic plaques in the coronary arteries or by fresh thrombosis secondary to the erosion.The number of ACS patients in China has been increasing year by year in recent years.The whole blood cell mainly includes three major categories:the red blood cell,white blood cell and blood platelet.When its expression level or the cell morphology changes and becomes abnormal,the complete blood count is often used as a blood test because of its potential to predict and indicate the development,progression,and prognosis of cardiovascular diseases,including ACS,to assess whether a person’s health is abnormal.It is found that the whole blood cell count and its classification are significantly correlated with the occurrence and prognosis of ACS.In addition,complete blood count(CBC)can be used as an effective clinical indicator in the evaluation of the effect of further intervention measures.Recent studies have confirmed that whole blood cells are the important factor affecting the occurrence and prognosis of ACS.Combing with the reports of ACS research,this paper reviews the researchs of whole blood cells and their classification count in predicting the risk of ACS.