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浅谈精子介导基因转移在畜牧业中的应用

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摘要 受精过程中,精子不仅能将自身的遗传信息传递给胚胎,还能将接触到的外来遗传信息进行传递,这种能力被称为精子介导基因的转移。1989年,与小鼠精子共同孵育的外源DNA在子代组织中表达并被检测到,这一发现极大促进了该项领域的发展。阐明SMGT作用的分子机制及开发稳定的生物技术用于生产转基因动物是其目标。畜牧业中,转基因动物的生产有着明确的目的性:如提高动物体胴体重、加快增长速度、改善饲料利用率、提高繁殖能力以及增强抗病能力等。本文简单回顾了家畜SMGT的研究现状,评估了转基因猪和牛应用的可能。
作者 金红梅 张亮
出处 《吉林畜牧兽医》 2022年第12期121-122,共2页 Jilin Animal Husbandry and Veterinary Medicine
关键词 精子 外源DNA
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  • 1Isabelle Galeraud-Denis,Sophie Lambard,Serge Carreau.Relationship between chromatin organization, mRNAs profile and human male gamete quality[J].Asian Journal of Andrology,2007,9(5):587-592. 被引量:11
  • 2Brackett B G. Uptake of heterologous genorne by mammalian spermatozoa and its transfer to ova through fertilization. Proceedings of the National Academy of Sciences USA, 1971, 68(2): 353-357.
  • 3Lavitrano M. Sperm cells as vectors for introducing foreign DNA into eggs: genetic transformation of mice. Cell, 1989, 57(5) 717-723.
  • 4Lavitrano M. Sperm-mediated gene transfer: production of pigs transgenic for a human regulator of complement activation. Transplantation Proceedings, 1997, 29(8): 3508-3509.
  • 5Fan L C, Collodi E Progress towards cell-mediated gene transfer in zebrafish. Briefings in Functional Genomics and Proteomics, 2002, 1(2): 131-138.
  • 6Hoelker M. Quantification of DNA binding, uptake, transmission and expression in bovine sperm mediated gene transfer by RT-PCR: effect of transfection reagent and DNA architecture. Theriogenology, 2007, 67(6): 1097-1107.
  • 7Yin J. Sperm mediated human coagulation factor VIII gene transfer and expression in transgenie mice. Swiss Medical Weekly, 2009, 139(25-26): 364-372.
  • 8Collares T. Transgene transmission in chickens by sperm-mediated gene transfer after seminal plasma removal and exogenous DNA treated with dimethylsulfoxide or N,N-dimethylacetamide. Journal of Biosciences, 2011, 36(4):613-620.
  • 9Zhou W. Germline transformation of the silkworm Bombyx mori L. by sperm-mediated gene transfer. Biology of Reproduction, 2012, 87(6): 144.
  • 10Maione B. Sperm-mediated gene transfer in mice. Molecular Reproduction and Development, 1998, 50(4): 406-409.

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