p73基因rs6695978位点基因型与卵巢癌病理特征和预后的相关性分析

The correlation analysis of rs6695978 locus genotype of p73 gene with pathological features and prognosis of ovarian cancer patients

目的观察p73基因rs6695978位点基因型在卵巢癌患者中的分布情况,探讨p73基因rs6695978位点基因型与卵巢癌病理特征和预后的相关性,为临床诊断和治疗提供参考。方法选取2017年10月至2021年5月该院收治的76例卵巢癌患者作为研究对象,所有患者均接受基因测序,检测p73基因rs6695978位点的基因型分布情况。比较不同基因型患者临床特征指标和预后,分析影响卵巢癌患者p73基因rs6695978位点基因型的相关因素。结果p73基因rs6695978位点不同基因型患者肿瘤最大径、肿瘤分期、分化程度比较,差异均有统计学意义(P<0.05)。多元逐步回归分析结果显示,肿瘤分期、分化程度与p73基因rs6696978位点基因型分布密切相关(P<0.05)。GG基因型患者32例,中位随访时间27.56个月,死亡10例,存活22例,生存率为68.75%,GA+AA基因型患者44例,中位随访时间28.01个月,死亡24例,存活20例,生存率为45.45%,不同基因型患者生存率比较,差异有统计学意义(P<0.05)。结论p73基因rs6695978位点基因型分布与卵巢癌患者病理特征和预后相关,携带A等位基因的卵巢癌患者预后更差。

Objective To observe the distribution of rs6695978 locus genotype of p73 gene in ovarian cancer patients,and investigate the correlation between rs6695978 locus genotype of p73 gene and pathological features and prognosis of ovarian cancer to provide reference for clinical diagnosis and treatment.Methods A total of 76 patients with ovarian cancer admitted to Northwest Women is and Children′s Hospital from October 2017 to May 2021 were selected as the research subjects.All patients received gene sequencing.The genotype distribution of rs6695978 locus of p73 gene was detected.The clinical characteristics and prognosis of patients with different genotype were compared.The related factors,which affected the genotype of rs6695978 locus of p73 gene were analyzed.Results There were statistically significant differences in tumor diameter,tumor stage and differentiation degree among patients with different genotype at rs6695978 locus of p73 gene(P<0.05).The multiple step regression analysis showed that the tumor stage and differentiation were closely related to genotype distribution of rs6696978 locus of p73 gene(P<0.05).There were 32 patients with GG genotype.The median follow-up time was 27.56 months.Ten patients died and 22 survived,the survival rate was 68.75%.There were 44 patients with GA+AA genotype,and the median follow-up time was 28.01 months.Totally 24 patients died and 20 patients survived,the survival rate was 45.45%.The survival rate of patients with different genotype was significantly different(P<0.05).Conclusion The genotype distribution of rs6695978 locus of p73 gene is correlated with the pathological features and prognosis of ovarian cancer patients,and the prognosis of ovarian cancer patients carrying A allele is worse.