胱抑素C、MPV/PLT对冠心病的影响及临床意义

The effect and clinical significance of cystatin-C and MPV/PLT on coronary heart disease

目的探讨胱抑素C、平均血小板体积/血小板计数(MPV/PLT)对冠心病的影响及临床意义。方法选取2021年7月至2022年6月该院心内科已完善冠状动脉造影检查的200例患者作为研究对象,根据冠状动脉造影结果分为冠心病组(163例)和非冠心病组(对照组,37例),比较两组胱抑素C、MPV/PLT。再依据Gensini评分将冠心病组分为3个亚组:<30分为低分组(74例)、30~60分为中分组(48例)、>60分为高分组(41例),比较各亚组胱抑素C、MPV/PLT及冠状动脉狭窄数量;采用Spearman相关进行相关性分析;采用多因素Logistic回归分析冠心病的危险因素。结果对照组和冠心病组C反应蛋白(CRP)、胱抑素C水平比较,差异均有统计学意义(P<0.05);对照组和冠心病组MPV/PLT比较,差异无统计学意义(P>0.05)。冠心病组不同亚组胱抑素C、冠状动脉狭窄数量比较,差异均有统计学意义(P<0.05);冠心病组不同亚组MPV/PLT比较,差异无统计学意义(P>0.05)。胱抑素C水平、冠状动脉狭窄数量与Gensini评分均呈正相关(r=0.396、0.506,P<0.05),胱抑素C及CRP水平升高是冠心病的危险因素(P<0.05)。结论胱抑素C对冠心病早期诊断和冠状动脉狭窄程度评估有重要价值,可为临床冠心病的病情评估提供指导。

Objective To explore the effect of cystatin-C and mean platelet volume/platelet count ratio(MPV/PLT)on coronary heart disease and its clinical guiding significance.Methods A total of 200 patients who had completed coronary angiography in the Department of Cardiology of our hospital from July 2021 to June 2022 were selected as the study subjects.They were divided into coronary heart disease group(163 cases)and control group(37 cases).Cystatin-C and MPV/PLT were compared between the two groups.The coronary heart disease group was then divided into three subgroups according to the Gensini score:≤30 was divided into low group(74 cases),30-60 was divided into middle group(48 cases),>60 was divided into high group(41 cases).Cystatin-C,MPV/PLT and the number of coronary stenosis were compared among the groups.Multivariate Logistic regression was used to analyze the risk factors of coronary heart disease.Results There were significant differences in CRP and cystatin-C between the control group and coronary heart disease group(P<0.05),but there were no significant difference in MPV/PLT(P>0.05).There were significant differences in cystatin-C and the number of coronary stenosis in different groups of coronary heart disease(P<0.05).There was no significant difference in MPV/PLT(P>0.05).Cystatin-C and the number of coronary stenosis were positively correlated with Gensini score(r=0.396,0.506,P<0.05),and elevated levels of cystatin C and CRP are risk factors for coronary heart disease(P<0.05).Conclusion Cystatin-C has important predictive value for the early diagnosis of coronary heart disease and the assessment of coronary stenosis,and can provide guidance for clinical assessment of coronary heart disease.