五味扶正益精汤对男性不育患者精子DNA完整性的影响

Effect of Wuwei Fuzheng Yijing Decoction on Sperm DNA Integrity in Male Infertility Patients

目的:观察五味扶正益精汤对男性不育患者精子DNA完整性的影响。方法:将符合纳入标准的100例脾肾气虚兼血瘀型精子DNA损伤的男性不育患者,随机分为观察组(五味扶正益精汤)和对照组(左卡尼汀口服溶液)各50例。治疗12周后观察、比较两组治疗前后精子DNA碎片指数(DFI)、中医证候评分及前向运动精子活力(PR)、精子存活率、精子浓度。结果:观察组总有效率为89.80%(44/49),对照组总有效率为62.50%(30/48),观察组明显高于对照组,差异有统计学意义(P<0.05)。与本组治疗前比较,治疗后两组患者DFI、中医证候积分均明显降低,PR、精子存活率及精子浓度均明显升高(P<0.05);与对照组治疗后比较,观察组上述指标均优于对照组(P<0.05)。结论:五味扶正益精汤能明显修复男性不育患者的精子DNA,改善精子质量,且具有较好的安全性。

Objective:To observe the effect of Wuwei Fuzheng Yijing decoction on sperm DNA integrity in male infertility patients.Method:One hundred male infertility patients with sperm DNA damage(spleen and kidney Qi deficiency and blood stasis)that met the inclusion criteria were randomly divided into an observation group(Wuwei Fuzheng Yijing decoction)and a control group(L-carnitine oral solution),with50 cases in each group.After 12 weeks of treatment,the DNA fragmentation index(DFI)and traditional Chinese medicine(TCM)syndrome score,progressive sperm motility(PR),sperm survival rate,and sperm concentration of the two groups before and after treatment were observed and compared.Result:The total effective rate of the observation group was 89.80%(44/49)higher than 62.50%(30/48)of the control group(P<0.05).Compared with the conditions before treatment,the DFI and TCM syndrome score of the two groups were reduced after treatment,while the PR,sperm survival rate,and sperm concentration were increased(P<0.05),and the observation group was superior to the control group in terms of the above indexes(P<0.05).Conclusion:Wuwei Fuzheng Yijing decoction obviously repairs sperm DNA of male infertility patients and improves sperm quality,with high safety.