巨噬细胞迁移抑制因子与肿瘤关系的研究进展

Research progress of the relationship between macrophage migration inhibitory factor and tumor

巨噬细胞迁移抑制因子(MIF)作为一种多效性细胞因子和宿主免疫的调节分子,在机体免疫和疾病中发挥重要作用。MIF具有癌基因特性,其高表达可促进癌细胞存活、增殖、迁移、侵袭、转移、血管生成并抑制凋亡。MIF与抗肿瘤免疫密切相关,基于MIF为靶点的特异性抑制剂目前尚未得到广泛应用。本文就MIF在肿瘤发生和进展中的作用、机制、治疗靶点等方面的研究进展进行综述,展望基于MIF为靶点的抑制剂运用在肿瘤防治中的意义。

Macrophage migration inhibitory factor(MIF),as a multipotent cytokine and regulatory molecule of host immunity,plays an important role in immunity and disease.MIF possesses the characteristics of oncogene,and MIF overexpression can promote cancer cell survival,proliferation,migration,invasion,metastasis,angiogenesis,and inhibit apoptosis.MIF is closely related to anti-tumor immunity.At present,the inhibitors specific for MIF have not been widely used.This article summarizes the research progress on the contribution,mechanism,and therapeutic targets of MIF in tumorigenesis and progression,and looks forward to the significance of the application of inhibitors based on MIF in tumor prevention and treatment.