氨溴特罗联合孟鲁司特钠治疗小儿急性支气管肺炎的临床效果

Clinical Effects of Amiloride Combined with Montelukast Sodium in the Treatment of Pediatric Acute Bronchopneumonia

目的对小儿急性支气管肺炎患者使用氨溴特罗联合孟鲁司特钠治疗的效果进行探讨。方法选取2019年2月—2021年10月期间中国人民解放军联勤保障部队第九六一医院收治的66例小儿急性支气管肺炎患儿为研究对象,根据随机抽样法分为两组,每组33例。常规组使用氨溴特罗进行治疗,研究组使用氨溴特罗联合孟鲁司特钠进行治疗,观察两组治疗效果(治疗有效率、症状消失时间、住院时间、血气分析指标、肺功能指标)。结果研究组治疗有效率(96.97%)、咳嗽消失时间(4.20±0.57)d、喘息消失时间(4.60±0.91)d、肺内湿啰音消失时间(4.86±1.21)d、发热消失时间(2.56±0.73)d、住院时间(6.46±0.57)d均优于常规组,差异有统计学意义(χ^(2)=4.631,P=0.031;t=12.711、8.789、6.194、5.849、20.469,P<0.001);治疗后,研究组酸碱度(7.38±0.05)、血氧分压(86.31±9.67)mmHg、二氧化碳分压(35.03±2.13)mmHg、最大呼气流量(7.56±1.34)L/s、第一秒用力呼气容积(3.91±1.02)L均优于常规组,差异有统计学意义(t=3.653、6.605、8.927、7.885、5.211,P<0.001)。结论急性支气管肺炎患儿通过氨溴特罗与孟鲁司特钠联合治疗后,其症状能够明显好转,可促进肺功能快速恢复,治疗效果显著。

Objective To investigate the effect of treatment with amiloride combined with montelukast sodium in pediatric patients with acute bronchopneumonia.Methods 66 children with acute bronchopneumonia admitted to the 961st Hospital of Joint Logistic Support Force of the People's Liberation Army from February 2019 to October 2021 were selected as the research objects.According to the random sampling method,they were divided into two groups,33 cases in each group.The conventional group was treated with ambroxol,and the study group was treated with ambroxol combined with montelukast sodium.The therapeutic effects of the two groups were observed(therapeutic efficiency,time of symptom disappearance,hospital stay,blood gas analysis index,and pulmonary function index).Results The effective rate(96.97%),cough disappeared(4.20±0.57)d,wheezing disappeared(4.60±0.91)d,wet rales in lung disappeared(4.86±1.21)d,fever disappeared(2.56±0.73)d,hospital stay(6.46±0.57)d in the study group were better than those in the conventional group,and the difference was statistically significant(χ^(2)=4.631,P=0.031;t=12.711,8.789,6.194,5.849,20.469,P<0.001).After treatment,pH(7.38±0.05),partial pressure of blood oxygen(86.31±9.67)mmHg,partial pressure of carbon dioxide(35.03±2.13)mmHg,maximum expiratory flow(7.56±1.34)L/s,forced expiratory volume in first second(3.91±1.02)L in the study group were better than those in the conventional group,and the difference was statistically significant(t=3.653,6.605,8.927,7.885,5.211,P<0.001).Conclusion After combined treatment with amiloride and montelukast sodium,the symptoms of children with acute bronchopneumonia can be significantly improved,which can promote rapid recovery of lung function.