APTT、FIB和D-二聚体诊断深静脉血栓形成的价值研究

Value of APTT,FIB and D-dimer in the Diagnosis of Deep Venous Thrombosis

目的探究活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)和D-二聚体诊断深静脉血栓形成的价值研究。方法选择2020年1月-2021年8月在东莞市松山湖中心医院就诊的深静脉血栓患者80例为观察组,另取80例健康体检者为对照组。取所有研究对象的空腹抗凝静脉血2mL,使用全自动血液分析仪检测APTT、FIB和D-二聚体水平,分析比较两组指标。结果和对照组相比,观察组患者的血清FIB和D-二聚体水平升高,APTT水平降低,差异均有统计学意义(P<0.05);三者联合检测的诊断灵敏性均高于任一指标单独检测,差异有统计学意义(P<0.05),三者联合检测的诊断特异性和任一指标单独检测的特异性间的差异无统计学意义(P>0.05);单因素分析结果显示,APTT是深静脉血栓形成的保护因素(P<0.05),FIB和D-二聚体是深静脉血栓形成的危险因素(P<0.05);多因素分析结果显示,FIB和D-二聚体是深静脉血栓形成的独立危险因素(P<0.05)。结论FIB和D-二聚体在深静脉血栓形成患者中血清水平显著升高,APTT水平降低,FIB、D-二聚体和APTT联合检测对深静脉血栓形成有较好的诊断价值。

Objective To investigate the activated partial thromboplastin time(APTT),fibrinogen(FIB)and D-dimer in the diagnosis of deep venous thrombosis.Methods 80 patients with deep venous thrombosis in Dongguan Songshanhu Central Hospital from January 2020 to August 2021 were selected as the observation group and 80 healthy persons as the control group.2mL of fasting anticoagulant venous blood of all subjects were taken,and the levels of APTT,FIB and D-dimer were detected by automatic blood analyzer.The indexes of the two groups were analyzed and compared.Results Compared with the control group,the levels of serum FIB and D-dimer in the observation group increased and the level of APTT decreased,and the difference was statistically significant(P<0.05);the diagnostic sensitivity of the combined detection of the three was higher than that of any index detected alone,and the difference was statistically significant(P<0.05).There was no statistically significant difference between the diagnostic specificity of the combined detection of the three and that of any index detected alone(P>0.05);univariate analysis showed that APTT was the protective factor of deep venous thrombosis(P<0.05),FIB and D-dimer were the risk factors of deep venous thrombosis(P<0.05);multivariate analysis showed that FIB and D-dimer were independent risk factors of deep venous thrombosis(P<0.05).Conclusion The serum levels of FIB and D-dimer were significantly increased and the levels of APTT were decreased in patients with deep venous thrombosis.The combined detection of FIB,D-dimer and APTT has a good diagnostic value for deep venous thrombosis.