慢阻肺缓解期采用特布他林及福多司坦的疗效评价

Curative Effect Evaluation of Terbutaline and Fudosteine for Patients with Chronic Obstructive Pulmonary Disease in Remission

目的评价慢阻肺缓解期采用特布他林及福多司坦的疗效。方法本次研究纳入对象均在本院收治的慢阻肺缓解期患者中,纳入时间为2019年8月-2020年7月。通过纳入和排除标准筛选出82例患者参与研究。将这些研究对象随机平均分成对照组和观察组,每组41例。对照组治疗药物为福多司坦片。观察组治疗药物为福多司坦片和硫酸特布他林雾化液。之后将治疗效果、炎性因子指标(IL-6、IL-8)、血气分析指标(PaO_(2)、PaCO_(2)、pH)、肺功能指标(PEFR、MMF、FVC、FEV_(1))、不良反应进行对比。结果经统计下分析,两组治疗总有效率的差异对比有统计学意义(P<0.05),观察组更高。治疗后两组IL-6、IL-8的差异对比,有统计学意义(P<0.05),观察组更低。治疗后两组PaO_(2)、PaCO_(2)、pH的差异对比,有统计学意义(P<0.05),观察组更高。治疗后两组PEFR、MMF、FVC、FEV_(1)的差异对比,有统计学意义(P<0.05),观察组更高。两组不良反应发生率的差异对比无统计学意义(P>0.05)。结论慢阻肺缓解期采用特布他林及福多司坦治疗的效果确切,能减少炎性因子,调节血气指标,改善肺功能,且安全性尚佳。

Objective To evaluate curaitve effect of terbutaline and fudosteine in remission of COPD.Methods The paper collected 82 cases COPD patients in remission in our hospital from August 2019 to July 2020 based on inclusion and exclusion criteria as study subjects,and divided them into control group and observation group randomly,with 41 cases in each group.Control group was treated with fudosteine tablets,and observation group with fudosteine tablets and terbutaline sulfate aerosol.Curative effect,inflammatory factor indicators(IL-6,IL-8),blood gas analysis indicators(PaO_(2),PaCO_(2),pH),pulmonary function indicators(PEFR,MMF,FVC,FEV_(1)),and adverse reactions were compared.Results According to statistical analysis,difference of total effective rate between two groups was statistically significant(P<0.05),that of observation group was higher.After treatment,difference of IL-6 and IL-8 between two groups was statistically significant(P<0.05).After treatment,difference of PaO_(2),PaCO_(2) and pH between two groups was statistically significant(P<0.05),that of observation group was higher.After treatment,difference of PEFR,MMF,FVC and FEV_(1) between two groups was statistically significant(P<0.05).There was no significant difference in incidence of adverse reactions between two groups(P>0.05).Conclusion Terbutaline and fudosteine can achieve effect in treatment of COPD in remission,reduce inflammatory factors,regulate blood gas indicators,improve lung function,which has good safety.