运动疗法、塞来昔布联合盐酸氨基葡萄糖对膝骨关节炎患者的疗效及炎性指标的影响

The Effect of Exercise Therapy,Celecoxib Combined with Glucosamine Hydrochloride on Knee Osteoarthritis Patients and the Effect of Inflammatory Indexes

目的探讨盐酸氨基葡萄糖辅助运动疗法与塞来昔布治疗膝骨关节炎(KOA)患者的临床效果,旨在为寻找有效治疗该病的方式提供参考。方法选取2021年1月-2022年1月本院骨科收治且经筛选后符合纳入标准的80例KOA患者进行前瞻性研究,将患者进行数字编码后,以随机数字表法将其分为对照组和研究组,每组40例。对照组患者在运动疗法基础上给予塞来昔布治疗;研究组则给予盐酸氨基葡萄糖辅助运动疗法及塞来昔布治疗。采用骨性关节炎指数(WOMAC)评分对患者临床疗效进行评估,并对患者治疗前后血沉(ESR)、血清降钙素原(PCT)、C反应蛋白(CRP)等炎性指标水平进行检测。结果治疗1个疗程、3个疗程后评估,研究组WOMAC评分低于对照组,差异有统计学意义(t=3.619、3.296,P<0.05);治疗3个疗程后炎性指标水平检测,研究组ESR、PCT、CRP水平均低于对照组(P<0.05)。结论在运动疗法联合塞来昔布治疗膝骨关节炎的同时,辅以盐酸氨基葡萄糖治疗,能够进一步改善患者炎症状态,促进患者膝关节症状改善,提高治疗效果。

Objective To explore the clinical effect of glucosamine hydrochloride-assisted exercise therapy and celecoxib in the treatment of patients with knee osteoarthritis(KOA),in order to provide reference for finding an effective way to treat the disease.Methods From January 2021 to January 2022,80 KOA patients who were admitted to the Orthopedics Department of our hospital and met the inclusion criteria after screening were selected for prospective study.They were divided into the control group and study group,with 40 cases in each group.The control group was given celecoxib on the basis of exercise therapy;and the study group was given glucosamine hydrochloride-assisted exercise therapy and celecoxib.The clinical efficacy of the patients was evaluated by the osteoarthritis index(WOMAC)score,and the levels of inflammatory indexes such as erythrocyte sedimentation rate(ESR),serum procalcitonin(PCT),and C-reactive protein(CRP)were detected before and after treatment.Results After 1 course of treatment and 3 courses of treatment,the WOMAC score of the study group was lower than that of the control group,and the difference was statistically significant(t=3.619,3.296,P<0.05).The levels of ESR,PCT and CRP in the study group were lower than those in the control group(P<0.05).Conclusion Exercise therapy combined with celecoxib in the treatment of knee osteoarthritis,supplemented with glucosamine hydrochloride treatment,can further improve the inflammatory state of patients,promote the improvement of knee joint symptoms,and improve the therapeutic effect.