胎盘早剥产后大出血行缩宫素及米索联合卡前列素氨丁三醇的效果

The Effect of Oxytocin and Miso Combined with Carprost Tromethamine for Massive Hemorrhage After Premature Abruption of Placenta

目的分析胎盘早剥产后大出血行缩宫素及米索联合卡前列素氨丁三醇的效果。方法选择本院在2019年2月-2020年10月接收的94例胎盘早剥产后大出血者作为观察对象,通过随机数表法将其分为参照组和研究组,参照组共计47例,治疗药物选择卡前列素氨丁三醇,研究组共计47例,治疗药物选择缩宫素、米索、卡前列素氨丁三醇,观察两组治疗前后的各项凝血指标变化,同时比较其治疗后不同时段的产后出血量、止血时间、住院时间以及治疗满意率差异。结果治疗前,组间各项凝血指标比较无统计学意义(P>0.05);治疗后,研究组APTT明显低于参照组,PT明显低于参照组,TT明显低于参照组,D-D明显低于参照组,Fbg明显高于参照组,不同时段的产后出血量均明显少于参照组,止血时间明显短于参照组,住院时间明显短于参照组,治疗总满意率明显高于参照组,差异均有统计学意义(P<0.05)。结论缩宫素联合米索和卡前列素氨丁三醇在胎盘早剥产后大出血者中具有良好治疗效果,对其凝血指标具有良好改善作用,能够快速控制出血,提高患者治疗满意度。

Objective To analyze the effect of oxytocin and misotoxin combined with carprost tromethamine for massive hemorrhage after placental abruption.Methods The study selected 94 patients with massive hemorrhage after premature abruption and delivery in our hospital from February 2019 to October 2020 as the observation objects.They were divided into the reference group and the study group by the random number table method.There were 47 cases in the reference group who received carprost tromethamine,and 47 cases in the study group who chose oxytocin,miso,carprost tromethamine,to observe the changes of various coagulation indicators before and after treatment in the two groups,and compare the amount of postpartum hemorrhage,hemostasis time,hospitalization time and treatment satisfaction rate after treatment in different periods.Results Before treatment,the comparison of coagulation indexes between the groups was not statistically significant(P>0.05).After treatment,APTT of the study group was significantly lower than that of the reference group,PT was significantly lower than that of the reference group,TT was significantly lower than that of the reference group,and D-D was significantly lower than that of the reference group,Fbg was significantly higher than that of the reference group,the postpartum hemorrhage in different periods was significantly less than that of the reference group,the bleeding time was significantly shorter than that of the reference group,the hospital stay was significantly shorter than the reference group,and the total satisfaction rate of treatment was significantly higher than that of the reference group.All were statistically significant(P<0.05).Conclusion Oxytocin combined with miso and carprost tromethamine has a good therapeutic effect in patients with massive hemorrhage after placental abruption,with a good effect on improving coagulation indicators,which can quickly control bleeding and improve patient satisfaction with treatment.