摘要
目的探讨幽门螺杆菌(Hp)及其相关胃黏膜病变与结直肠肿瘤的相关性。方法选取2019年11月—2020年10月在惠州市中心人民医院同时行胃肠镜及胃黏膜活检快速尿素酶检测的1188例患者,根据病理结果分为结直肠肿瘤组439例和对照组749例。收集结直肠肿瘤患者肿瘤的部位、大小、数量、病理分型、病理严重程度、分化程度等资料,采用卡方检验、Pearson检验、Logistic回归模型比较各组Hp感染情况,分析Hp相关胃黏膜病变与结直肠肿瘤发生的关系。结果卡方检验及Pearson相关性分析提示Hp感染与结直肠肿瘤的发生相关;Logistic回归分析并校正年龄、性别后,提示Hp感染是结直肠腺瘤、腺癌发生的重要促进因素(OR=1.924、2.045)。在439例结直肠肿瘤患者中,Hp感染在腺瘤的数量和大小方面的差异有统计学意义(P<0.05)。不同Hp相关胃黏膜病变(慢性胃炎、胃增生性病变及胃肿瘤性病变)与结直肠腺瘤发生均相关(P<0.05)。结论Hp感染是结直肠肿瘤的危险因素,Hp感染合并胃黏膜病变者更易发生结肠多发腺瘤。
Objective To investigate the correlations of Helicobacter pylori(Hp)and its related gastric mucosal lesions with colorectal neoplasms.Methods A total of 1188 patients with rapid urease detection by gastroenteroscopy and gastric mucosal biopsy at the same time in the Huizhou City Central People′s Hospital from November 2019 to October 2020 were enrolled,and they were divided into colorectal neoplasia group with 439 cases and control group with 749 cases according to pathological results.The location,size,the number,pathological classification and severity of neoplasms in patients with colorectal neoplasms were collected,the condition of Hp infection was compared between two groups by Chi-square test,Pearson test and Logistic regression model,and the relationship between Hp related gastric mucosal lesions and colorectal neoplasms was analyzed.Results Chi-square test and Pearson analysis suggested that Hp infection was related to the occurrence of colorectal neoplasms;the Logistic regression analysis and adjustment for age and gender indicated that Hp infection was an important facilitating factor of colorectal adenoma and adenocarcinoma(OR=1.924,2.045).In 439 patients with colorectal neoplasms,there were significant differences in the number and size of adenomas for Hp infection(P<0.05).Different Hp related gastric mucosal lesions(chronic gastritis,gastric hyperplastic lesions,and gastric neoplastic lesions)were associated with the occurrence of colorectal adenoma(P<0.05).Conclusion Hp infection is a risk factor for colorectal neoplasms,and patients with Hp infection and gastric mucosal lesions are more likely to develop multiple adenomas of colon.
作者
胡旭辉
饶文辉
袁辉
陈丽莎
许良锋
陈惠新
HU Xuhui;RAO Wenhui;YUAN Hui;CHEN Lisha;XU Liangfeng;CHEN Huixin(Department of Gastroenterology,Central People′s Hospital of Huizhou City in Guangdong Province,Huizhou,Guangdong,516001)
出处
《实用临床医药杂志》
CAS
2022年第23期14-19,共6页
Journal of Clinical Medicine in Practice
基金
广东省惠州市科技计划项目(2019Y054)。
关键词
幽门螺杆菌
结直肠肿瘤
胃黏膜病变
腺瘤
腺癌
病理分型
Helicobacter pylori
colorectal neoplasms
gastric mucosa lesions
adenoma
adenocarcinoma
pathological classification