重复经颅磁刺激联合氨磺必利治疗精神分裂症的效果及对认知功能的影响

Effect of repetitive transcranial magnetic stimulation combined with amisulpride in treatment of schizophrenia and its influence on cognitive function

目的观察重复经颅磁刺激(rTMS)联合氨磺必利治疗精神分裂症的效果及对患者认知功能的影响。方法选取100例精神分裂症患者作为研究对象,随机分为研究组和对照组,每组50例。对照组患者采用氨磺必利治疗,研究组患者采用氨磺必利联合rTMS治疗,比较2组患者的临床症状评分、治疗效果和认知功能评分。结果治疗前,2组临床症状评分比较,差异无统计学意义(P>0.05);治疗后,研究组一般精神病理评分、阳性症状评分、阴性症状评分依次为(30.13±1.23)、(12.31±2.01)、(17.91±4.15)分,分别低于对照组的(33.17±2.15)、(14.31±1.33)、(20.31±3.17)分,差异有统计学意义(P<0.05)。研究组治疗总有效率为96.00%(48/50),高于对照组的68.00%(34/50),差异有统计学意义(P<0.05)。治疗前,2组认知功能评分比较,差异无统计学意义(P>0.05);治疗后,研究组认知功能各维度评分和总分均高于对照组,差异有统计学意义(P<0.05或P<0.01)。结论相较于单独氨磺必利治疗,采用rTMS联合氨磺必利治疗精神分裂症患者可提升治疗效果,改善患者认知功能,减轻患者症状。

Objective To observe the effect of repetitive transcranial magnetic stimulation(rTMS)combined with amisulpride in the treatment of schizophrenia and its influence on cognitive function.Methods A total of 100 schizophrenia patients were enrolled as study objects,and they were randomly divided into study group and control group,with 50 patients in each group.The control group was treated with amsulpiride,and the study group was treated with amsulpiride combined with rTMS.The clinical symptom score,therapeutic effect and cognitive function score of the two groups were compared.Results Before treatment,there was no significant difference in clinical symptom score between the two groups(P>0.05).After treatment,the general psychopathological score,positive symptom score,and negative symptom score of the study group were(30.13±1.23),(12.31±2.01),(17.91±4.15),which were lower than(33.17±2.15),(14.31±1.33),(20.31±3.17),respectively in the control group(P<0.05).The total effective rate of the study group was 96.00%(48/50),which was higher than 68.00%(34/50)of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in cognitive function score between the two groups(P>0.05).After treatment,the item scores of all dimensions of cognitive function and total score in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05 or P<0.01).Conclusion In the treatment of schizophrenia patients,r TMS combined with amisulpride can improve cognitive function and therapeutic effect,and relieve mental symptoms compared with amisulpride treatment alone.