摘要
目的探讨胃癌患者的血清miRNA-93水平及与临床特征和预后的关系。方法选取82例胃癌患者和82例胃部良性疾病患者,分别作为恶性组和良性组,比较两组患者的血清miRNA-93水平。采用受试者工作特征(ROC)曲线及曲线下面积(AUC)分析血清miRNA-93水平对胃癌的诊断价值。以血清miRNA-93水平的中位值为界,将胃癌患者分为miRNA-93高表达组和miRNA-93低表达组,比较两组患者的临床特征,采用Spearman相关分析法分析血清miRNA-93水平与胃癌患者临床特征的相关性。随访3年,记录胃癌患者预后,采用Cox比例风险回归模型分析血清miRNA-93水平与胃癌患者预后的关系。结果恶性组患者血清miRNA-93水平明显高于良性组(P﹤0.01)。血清miRNA-93水平对胃癌具有中等诊断价值,AUC为0.852。miRNA-93高表达组中肿瘤直径≥5 cm、低分化、Ⅲ~Ⅳ期、有淋巴转移的患者比例均高于miRNA-93低表达组,差异均有统计学意义(P﹤0.05)。血清miRNA-93水平与胃癌患者的肿瘤直径、分化程度、TNM分期、淋巴结转移情况均呈正相关(P﹤0.01)。miRNA-93高表达组患者预后不良发生率高于miRNA-93低表达组患者(P﹤0.05),血清miRNA-93高表达是胃癌患者预后不良的独立危险因素(OR=2.488,P﹤0.05)。结论血清miRNA-93水平对胃癌具有中等诊断价值,其与胃癌患者的临床特征具有相关性,其高表达是胃癌患者预后不良的危险因素。
Objective To investigate the serum level of miRNA-93 in gastric cancer patients and its relationship with clinical characteristics and prognosis.Method A total of 82 patients with gastric cancer and 82 patients with benign gastric diseases were selected as malignant group and benign group,respectively.The serum miRNA-93 levels were compared between the two groups.The receiver operating characteristics(ROC)curve and area under the curve(AUC)were used to analyze the diagnostic value of serum miRNA-93 level for gastric cancer.Based on the median serum miRNA-93level,gastric cancer patients were divided into miRNA-93 high-expression group and miRNA-93 low-expression group,the clinical characteristics of patients in the two groups were compared.Spearman correlation analysis was used to analyze the correlation between serum miRNA-93 level and the clinical characteristics of gastric cancer patients.Follow-up for 3 years and documented the prognosis of patients with gastric cancer.The Cox proportional hazards regression model was used to analyze the relationship between serum miRNA-93 level and the prognosis of gastric cancer patients.Result The serum miRNA-93 level in the malignant group was significantly higher than that in the benign group(P<0.01).Serum miRNA-93 level had moderate diagnostic value for gastric cancer,with AUC of 0.852.The proportion of patients with tumor diameter≥5 cm,poorly differentiated,stage III-IV,and lymphatic metastasis in the miRNA-93 high-expression group were higher than those in the miRNA-93 low-expression group,and the differences were statistically significant(P<0.05).Serum miRNA-93 level was positive correlated with tumor diameter,degree of differentiation,TNM stage,and lymph node metastasis of gastric cancer patients(P<0.01).The incidence of poor prognosis in the miRNA-93 high-expression group was higher than that in the miRNA-93 low-expression group(P<0.05).Serum miRNA-93 high expression was an independent risk factor for poor prognosis in patients with gastric cancer(OR=2.488,P<0.05).Conclusion Serum miRNA-93 level has moderate diagnostic value for gastric cancer.The expression level of miRNA-93 is correlated with the clinical characteristics of gastric cancer patients,and its high expression is a risk factor for poor prognosis.
作者
杨茂省
杨到凤
李世杰
刘大宁
YANG Maosheng;YANG Daofeng;LI Shijie;LIU Daning(Department of Laboratory,Puyang Second People’s Hospital,Puyang 457000,He’nan,China;Department of Laboratory,Puyang People’s Hospital,Puyang 457000,He’nan,China)
出处
《癌症进展》
2022年第24期2545-2548,共4页
Oncology Progress
关键词
胃癌
miRNA-93
临床特征
预后
gastric cancer
miRNA-93
clinical characteristic
prognosis