Ki-67、肿瘤坏死因子-α及糖类抗原125在非霍奇金淋巴瘤患者中的表达及临床意义

Expression of Ki-67,tumor necrosis factor-α,and carbohydrate antigen 125 in patients with non-Hodgkin lymphoma and their clinical significance

目的探讨Ki-67、肿瘤坏死因子-α(TNF-α)、糖类抗原125(CA125)在非霍奇金淋巴瘤(NHL)患者中的表达及临床意义。方法选取85例NHL患者和37例淋巴结反应性增生患者,分别作为NHL组和对照组。根据治疗效果将NHL患者分为缓解组(n=49)和未缓解组(n=36)。比较NHL组和对照组患者的Ki-67、TNF-α及CA125表达情况;比较不同临床特征NHL患者的Ki-67、TNF-α及CA125表达情况;比较缓解组和未缓解组患者的Ki-67、TNF-α及CA125表达情况;分析Ki-67、TNF-α、CA125单独及联合检测对NHL的诊断价值。结果NHL组患者的Ki-67、TNF-α及CA125水平均明显高于对照组,差异均有统计学意义(P﹤0.01)。Ⅲ~Ⅳ期、中高危NHL患者的Ki-67、TNF-α及CA125水平分别明显高于Ⅰ~Ⅱ期、低危患者,差异均有统计学意义(P﹤0.01)。治疗后,缓解组患者的Ki-67、TNF-α及CA125水平均低于本组治疗前及未缓解组,差异均有统计学意义(P﹤0.05)。Ki-67、TNF-α、CA125联合检测诊断NHL的灵敏度、特异度及准确度均高于各指标单独检测,且与病理结果的一致性较好,Kappa=0.788。结论Ki-67、TNF-α及CA125水平与NHL患者的临床分期、肿瘤侵袭性及预后密切相关,三者联合检测对NHL患者的早期诊断及临床治疗具有重要的指导意义。

Objective To investigate the expression of Ki-67,tumor necrosis factor-α(TNF-α),and carbohydrate antigen 125(CA125)in patients with non-Hodgkin lymphoma(NHL)and their clinical significance.Method A total of 85NHL patients and 37 patients with reactive hyperplasia lymph nodes were selected as the NHL group and the control group,respectively.NHL patients were divided into response group(n=49)and unresponse group(n=36)according to the treatment effect.The expression of Ki-67,TNF-α,and CA125 in NHL group and control group were compared.The expression of Ki-67,TNF-α,and CA125 in NHL patients with different clinical characteristics were also compared.The expression of Ki-67,TNF-α,and CA125 in response group and unresponse group were compared.The diagnostic value of Ki-67,TNF-αand CA125 alone and in combination detection for NHL were analyzed.Result The levels of Ki-67,TNF-α,and CA125 in the NHL group were significantly higher than those in the control group,and the differences were statistically significant(P<0.01).The levels of Ki-67,TNF-α,and CA125 in stage III-IV,intermediate and high risk NHL patients were significantly higher than those in stage I-II and low risk patients,and the differences were statistically significant(P<0.01).After the treatment,the levels of Ki-67,TNF-α,and CA125 in the response group were lower than those before the treatment and unresponse group,and the differences were statistically significant(P<0.05).The sensitivity,specificity,and accuracy of combined detection of Ki-67,TNF-α,and CA125 in the diagnosis of NHL were higher than those of each index alone,the consistency with the pathological results was reliable,and the Kappa value was 0.788.CCoonn-clusion Ki-67,TNF-α,and CA125 levels were closely related to the clinical stage,tumor aggressiveness and prognosis of NHL patients.It has important guiding significance for the early diagnosis and clinical treatment of NHL patients through the combined detection of the three indicators.