薯蓣属植物中菲类化学成分及其药理活性研究进展

Research Progress on Phenanthrenes from Dioscorea Plants and Their Pharmacological Activities

薯蓣属(Dioscorea)植物是中药材的重要来源,山药、穿山龙、粉萆薢、黄山药、绵萆薢等中药皆来源于该属植物。菲类化合物是该属植物中一类重要的化学成分,包括菲单体、二氢菲、四氢菲、菲醌和菲二聚体5种结构类型,具有抗肿瘤、抗炎、抗氧化、降血糖、抗肥胖、抗菌、抗病毒、神经保护等药理活性,其中一些菲类化合物活性多样且作用显著,有较好的开发利用前景。目前未见针对薯蓣属植物中菲类化学成分的系统性综述报道,本文对薯蓣属植物中的菲类化学成分及其药理活性进行综述,旨在为相关研究提供参考,以促进薯蓣属植物的开发利用。

Dioscorea is an important source of traditional Chinese medicine,many traditional Chinese medicine such as Dioscoreae Rhizoma,Dioscoreae Nipponicae Rhizoma,Dioscorea Hypoglauca Rhizoma,Dioscoreae Panthaicae Rhizoma,Dioscoreae Spongiosae Rhizoma all come from this genus.Phenanthrene compounds are an important class of chemical constituents in this genus,including five structural types of phenanthrene monomer,dihydrophenanthrene,tetrahydrophenanthrene,phenanthrenequinone and phenanthrene dimer.They possess anti-tumor,anti-inflammatory,antioxidant,hypoglycemic,anti-obesity,antibacterial,antiviral,neuroprotective and other pharmacological activities.Some phenanthrenes from Dioscorea have various activities and significant effects,and have good prospects for development and utilization.At present,there has been no systematic review on phenanthrenes from Dioscorea plants.In this paper,the phenanthrenes from Dioscorea plants and their pharmacological activities are reviewed to provide reference for related studies and promote the development and utilization of Dioscorea plants.