宫缩抑制剂:钙通道阻滞剂的益处和风险

Uterine contraction inhibitor:the benefits and risks of calcium channel blockers

早产是造成婴儿发病率和死亡率增长的一个主要原因。各种宫缩抑制剂研究的目的是预防早产的发生,增加分娩时的胎龄,并预防与早产相关的并发症。本文旨在总结抗宫缩药的主要类别,并回顾与归纳相关研究资料。总结非甾体类消炎药、钙通道阻滞剂、硫酸镁和β2肾上腺素能受体激动剂的益处和风险。钙通道阻滞剂在延长妊娠期和降低新生儿发病率和死亡率方面有较好的疗效,并且不良反应也最小。宫缩抑制剂,尤其是钙通道阻滞剂,可能对孕妇及其婴儿有益。它们的使用应针对患者的具体情况具体分析,并与其他治疗策略结合使用。例如,使用糖皮质激素促进胎儿肺成熟或使用硫酸镁进行神经保护并转移到三级医疗中心救治。期望本研究可以促使妇产科医生、家庭医生能够更好地明确主要类别的宫缩抑制剂以及作用机制,并根据有关潜在益处和风险选择合适的宫缩抑制剂。

Preterm birth is a major cause of the increase in infant morbidity and mortality.The purpose of various contractions inhibitors studies is to prevent the occurrence of preterm birth,increase the gestational age at delivery,and prevent complications related to preterm birth.This paper aims to summarize the main categories of uterine contraction inhibitor and review the research data related to it.Summarize the benefits and risks of nonsteroidal anti-inflammatory drugs,calcium channel blockers,magnesium sulfate,andβ2 adrenergic receptor agonists.Calcium channel blockers have better efficacy in prolonging pregnancy and reducing neonatal morbidity and mortality,along with minimal adverse effects.Uterine contraction inhibitor,especially calcium channel blockers,may be beneficial for pregnant women and their infants.Their use should be patient-specific and used in combination with other treatment strategies.For example,the use of glucocorticoids to promote fetal lung maturation or magnesium sulfate for neuroprotection and transfer to tertiary medical centers requires the optimal use of these drugs.It is expected that this study will encourage obstetricians and gynecologists and family physicians to better define the major categories of uterine contraction inhibitor and the mechanisms of action and to select appropriate uterine contraction inhibitor based on the potential benefits and risks involved.