活血化痰通络法辅助治疗慢性阻塞性肺疾病急性加重期临床观察

Efficacy observation of method of activating blood circulation,dissipating phlegm and dredging collaterals for adjuvant treatment of acute exacerbation of chronic obstructive pulmonary disease

目的:观察活血化痰通络法辅助治疗慢性阻塞性肺疾病急性加重(AECOPD)的临床疗效。方法:将符合纳入标准的60例AECOPD患者随机分为两组各30例。对照组予AECOPD常规治疗,治疗组在对照组基础上联合使用活血化痰通络法治疗,疗程均为2周。比较两组临床疗效及股动脉的氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))及外周静脉血超敏C反应蛋白(hsCRP)、血沉(ESR)、血清降钙素原(PCT)等指标水平。结果:治疗组总有效率为93.33%,对照组的为70.00%,两组比较差异有统计学意义(P<0.05);治疗后,两组患者中医症状积分、PaCO_(2)、PaO_(2)及hs-CRP、ESR、PCT水平均较治疗前改善(P<0.05),且治疗组优于对照组(P<0.05)。结论:活血化痰通络法配合西医常规治疗可有效减轻COPD急性加重期患者临床症状,改善生活质量,还能有效改善其呼吸通气功能,减轻炎症反应,较单纯常规治疗临床疗效更好。

Objective:To observe the clinical efficacy of method of activating blood circulation,dissipating phlegm and dredging collaterals for adjuvant treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:60 cases of patients with AECOPD,who met the inclusion criteria,were randomly divided into two groups,30 cases in each group.The control group was treated with routine western medicine for AECOPD,while the treatment group was treated plus by method of activating blood circulation,dissipating phlegm and dredging collaterals on the basis of control group.For both groups,the course of treatment was 2 weeks.The clinical efficacy were compared between two groups.Results:The total effective rate was 93.33%in treatment group and 70.00%in control group respectively,and the comparative difference between two groups was statistically significant(P<0.05).After treatment in both groups,the scores of TCM symptoms and the levels of PaCO_(2),PaO_(2),hs-CRP,ESR and PCT of patients were improved compared with before treatment(P<0.05),and the treatment group was better than control group(P<0.05).Conclusion:The method of activating blood circulation,dissipating phlegm and dredging collaterals and routine western medicine can effectively reduce the clinical symptoms of patients with AECOPD,improve their quality of life,also effectively improve their respiratory and ventilatory functions and reduce the inflammatory reactions,which has a better clinical efficacy than treatment with simple routine western medicine.