基于fMRI技术探讨针刺太溪穴对血管性痴呆患者脑功能的影响

Approach to effect of needling at Taixi acupoint on brain function of patients with VD based on fMRI

目的:观察针刺太溪穴对血管性痴呆(VD)患者脑激活区分布规律的影响,探讨针刺太溪穴治疗VD的中枢效应机制。方法:分别采集18名VD患者针刺右侧太溪穴任务态fMRI数据,应用DPARSF、统计参数图(SPM12)及XJVIEW软件对数据进行后处理和统计分析。结果:针刺VD患者太溪穴正激活脑区:左内侧额上回,右侧额中回,右侧额上回;负激活脑区:左侧枕下回,双侧距状裂周围皮层,右侧颞中回,左侧后扣带回,左侧梭状回,右侧海马回,左侧枕中回,右侧角回,右侧缘上回。结论:针刺VD患者太溪穴发挥良性的双向调节作用,实现高级认知区、体感区、边缘系统和视觉听觉皮层的功能再平衡,也证实了针刺太溪穴治疗VD患者的有效性和可行性。

Objective:To observe the effect of needling at Taixi acupoint(KI3)on distribution law of brain activation region of patients with vascular dementia(VD),and to approach the central effect mechanism of treating VD by needling at KI3.Methods:Task-state fMRI data of needling at right KI3 of 18 patients with VD were collected.The data were post-processed and statistically analyzed by DPARSF,statistical parameter mapping(SPM12)and XJVIEW software.Results:Needling at KI3 of patients with VD activated brain region positively,i.e.left medial superior frontal gyrus,right middle frontal gyrus,right superior frontal gyrus;negatively activated brain region,i.e.left inferior occipital gyrus,bilateral calcarine fissure surrounding cortex and right middle temporal gyrus,left posterior cingulate gyrus,left fusiform gyrus,right hippocampal gyrus,left middle occipital gyrus,right angular gyrus and right supramarginal gyrus.Conclusion:Needling at KI3 of patients with VD plays a benign bidirectional regulating role,which realizes the functional rebalancing of advanced cognitive region,somatosensory region,limbic system,visual cortex and auditory cortex,also confirms the effectiveness and feasibility of treating patients with VD by needling at Taixi acupoint.