摘要
淋球菌耐药问题是性传播疾病防控中面临的巨大挑战,近年来在世界范围包括我国流行的头孢曲松耐药淋病奈瑟菌株FC428使耐药问题更加严峻。该菌株因含新型镶嵌结构的penA基因而对头孢曲松高度耐药,且已在全球广泛传播。为更好地了解FC428的特征,控制其进一步传播,本文综述其起源、传播、主要分子特征、耐药机制、检测方法以及临床治疗和耐药监测的策略。
Antimicrobial resistance of Neisseria gonorrhoeae has become a big challenge in the control and prevention of sexually transmitted diseases.Recently,a ceftriaxone-resistant Neisseria gonorrhoeae strain FC428 has spread across the world including China,which has worsened the antimicrobial resistance problem.This strain is highly resistant to ceftriaxone due to a novel mosaic penA gene.In order to better understand the characteristics of FC428 and control its further spread,this review summarizes its origin,spread,main molecular characteristics,resistance mechanisms,detection methods,and strategies for clinical treatment and antimicrobial resistance surveillance.
作者
陈绍椿
刘经纬
周可
尹跃平
Chen Shaochun;Liu Jingwei;Zhou Ke;Yin Yueping(Reference Laboratory of STD,Institute of Dermatology,Chinese Academy of Medical Sciences and Peking UnionMedical College,Nanjing 210042,China)
出处
《中华皮肤科杂志》
CAS
CSCD
北大核心
2022年第12期1122-1126,共5页
Chinese Journal of Dermatology
基金
"艾滋病和病毒性肝炎等重大传染病防治"科技重大专项(2018ZX10101001-004-003)
江苏省高层次卫生人才"六个一工程"拔尖人才项目(LGY2019091)
西藏自治区自然科学基金(XZ2021ZR-ZY47(Z))。
关键词
淋病奈瑟球菌
头孢曲松
抗药性
细菌
疾病传播
传染性
感染控制
FC428
Neisseria gonorrhoeae
Ceftriaxone
Drug resistance,bacterial
Disease transmission,infectious
Infectioncontrol
FC428
