摘要
高尿酸血症(hyperuricemia,HUA)是由嘌呤代谢紊乱或尿酸排泄障碍引起的一种慢性代谢性疾病,HUA实验动物模型是研究HUA病理机制和药物治疗作用的基础。该文综述了目前药物研究中常用的HUA实验动物模型,介绍了模型的造模原理、制备方法、物种选择和相关检测技术等,为应用该类模型开展研究提供参考。
Hyperuricemia is a chronic metabolic disease caused by purine metabolism disorder or uric acid excretion disorder.The experimental animal model of hyperuricemia is the basis for studying the pathological mechanism and drug treatment of hyperuricemia.This paper reviews the experimental animal models of hyperuricemia commonly used in drug research,and introduces the modeling principle,preparation methods,species selection and related detection techniques of the models,so as to provide reference for the application of such models in research.
作者
岳义松
张雯
谢逸菲
秦雪梅
杜冠华
YUE Yi-song;ZHANG Wen;XIE Yi-fei;QIN Xue-mei;DU Guan-hua(Modern Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan 030006,China;Beijing Key Lab of Drug Targets Identification and Drug Screening,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2023年第2期201-206,共6页
Chinese Pharmacological Bulletin
基金
国家重点研发计划(No 2020YFC2008302)
中国医学科学院医学与健康科技创新工程重大协同创新项目(No 2021-1-I2M-005)
国家自然科学基金资助项目(No 82004071)。
关键词
高尿酸血症
尿酸
动物模型
氧嗪酸钾
嘌呤
痛风
hyperuricemia
uric acid
animal model
potassium oxazine
purine
gout
