摘要
目的系统评价赛肤润在预防头颈部肿瘤放射治疗后放射性皮炎中的应用效果。方法计算机检索PubMed、Cochrane Library、Embase、Web of Science、CBM数据库、维普数据库、万方数据库和CNKI数据库,收集运用赛肤润预防放射性皮炎的随机对照研究,对照组使用其他预防用药或安慰剂或常规方式干预组使用赛肤润,检索时限为各数据库建库至2019年12月31日。由2名独立的评价者对文献进行筛选、质量评价和数据提取后,采用RevMan 5.3软件进行meta分析。结果共纳入符合标准的文献10篇,共计842例头颈部肿瘤患者。Meta分析结果显示:干预组放射性皮炎总发生率与对照组比较,差异有统计学意义[OR=0.24,95%CI(0.15,0.37),P<0.05];干预组Ⅰ级放射性皮炎发生率与对照组比较,差异有统计学意义[OR=2.70,95%CI(1.92,3.81),P<0.05];干预组Ⅱ级及以上放射性皮炎发生率与对照组比较,差异有统计学意义[OR=0.19,95%CI(0.13,0.27),P<0.05]。结论赛肤润能有效降低头颈部肿瘤放射性皮炎的发生率、减轻放射性皮炎的严重程度,降低Ⅱ级及以上放射性皮炎的发生率。
Objective To systematically evaluate the efficacy of Sanyrene in preventing radi⁃ation dermatitis after radiotherapy for head and neck tumors.Methods The data of PubMed,Co⁃chrane Library,Embase,Web of Science,CBM database,Viper database,Wanfang database and CNKI database were searched,and randomized controlled studies on the use of Sanyrene to prevent radiation dermatitis were collected.The intervention group used Sanyrene,and the con⁃trol group used other preventive medications or placebos or conventional methods(such as flush⁃ing with water).The search time limit is from the establishment of the database to December 31,2019.Two independent reviewers screened,evaluated and extracted the literature,and Meta-anal⁃ysis was performed by RevMan 5.3 software.Results A total of 10 articles that met the criteria were included,including 842 patients with head and neck tumor.Meta analysis results showed that the total incidence of radioactive dermatitis in the intervention group was statistically signifi⁃cant compared with the control group[OR=0.24,95%CI(0.15,0.37),P<0.05].The incidence of gradeⅠradiation dermatitis in the intervention group was significantly different from that in the control group[OR=2.70,95%CI(1.92,3.81),P<0.05].The incidence of gradeⅡradiation dermatitis or above in the intervention group was significantly different from that in the control group[OR=0.19,95%CI(0.13,0.27),P<0.05].Conclusion Sanyrene can effectively re⁃duce the incidence of radioactive dermatitis in head and neck tumors,alleviate the severity of ra⁃dioactive dermatitis,and reduce the incidence of radioactive dermatitis of gradeⅡand above.
作者
郑雅
曾谷清
彭玲英
倪晓燕
王傲一
潘荣佳
年芳
ZHENG Ya;ZENG Guqing;PENG Lingying;NI Xiaoyan;WANG Aoyi;PAN Rongjia;NIAN Fang(School of Nursing University of South China,Hengyang,Hunan,421001)
出处
《中西医结合护理》
2021年第3期50-55,共6页
Chinese Journal of Integrative Nursing
基金
2020年南华大学护理学院研究生科研创新项目(2020CX06)。